Evidence map›Paper›PMID 21917719›Full record

ArticleScience signaling2011

Introduction to network analysis in systems biology.

Avi Ma'ayan

Abstract read
In one paragraph

Article in Science signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed.

  1. PMconv: How to Compare Proteomes and Metabolomes?International journal of molecular sciences · 2026
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  6. A primer for quantum computing and its applications to healthcare and biomedical research.Journal of the American Medical Informatics Association : JAMIA · 2024
    Article
  7. Article
  8. Article
  9. Article
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  11. Review
  12. Article
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  14. Review
  15. Article
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  17. Article
  18. A practical two-sample test for weighted random graphs.Journal of applied statistics · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Avi Ma'ayanDepartment of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA. avi.maayan@mssm.edu

Funding

System Biology Center in New YorkP50GM071558 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI IYENGAR, SRINIVAS RAVI V · 2007 to 2017
$22.8M
Role of HIPK2 in Kidney Tubulointerstitial InjuryR01DK088541 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI HE, JOHN CIJIANG · 2010 to 2019
$4.0M
A Chemical Biology Network for Personalized MedicineRC2LM010994 · NLM · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARDOZO, TIMOTHY J, MA'AYAN, AVI · 2010 to 2010
$2.1M
Mount Sinai Institutes for Clinical and Translational SciencesKL2RR029885 · NCRR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI MURPHY, BARBARA T. · 2009 to 2011
$1.8M
NCRR NIH HHS KL2 RR029885NCRR NIH HHS L2RR029885-0109NIDDK NIH HHS 1R01DK088541-01A1NIDDK NIH HHS R01 DK088541NIGMS NIH HHS 5P50GM071558-03NIGMS NIH HHS P50 GM071558NIH HHS RC2OD006536-01NLM NIH HHS RC2 LM010994
6 · The paper itself

Abstract

This Teaching Resource provides lecture notes, slides, and a problem set for a set of three lectures from a course entitled "Systems Biology: Biomedical Modeling." The materials are from three separate lectures introducing applications of graph theory and network analysis in systems biology. The first lecture describes different types of intracellular networks, methods for constructing biological networks, and different types of graphs used to represent regulatory intracellular networks. The second lecture surveys milestones and key concepts in network analysis by introducing topological measures, random networks, growing network models, and topological observations from molecular biological systems abstracted to networks. The third lecture discusses methods for analyzing lists of genes and experimental data in the context of prior knowledge networks to make predictions.

Indexed as

Models, BiologicalNeural Networks, ComputerSystems Biology

Identifiers

PMID21917719
PMCPMC3196357

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.