Evidence map›Paper›PMID 21917598›Full record

ReviewJournal of dental research2012

Childhood rhabdomyosarcoma: recent advances and prospective views.

C Wang

Abstract readReview
In one paragraph

Review in Journal of dental research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

C WangDepartment of Oral Biology and Center for Molecular Biology of Oral Diseases, University of Illinois at Chicago, 801 South Paulina Street, RM530CB, m/c 860, Chicago, IL 60612, USA. chiayeng@uic.edu
University of Illinois Chicago · US

Funding

Basis of PAX3-FKHR oncogenesis in rhabdomyosarcomaR01CA074907 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI WANG, CHIAYENG · 2002 to 2011
$2.7M
REGULATION OF THE BREAST CELL DNA SYNTHESOMER01CA074904 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI HICKEY, ROBERT J · 1998 to 2000
$197k
NCI NIH HHS CA074904NCI NIH HHS R01 CA074907
6 · The paper itself

Abstract

Rhabdomyosarcoma (RMS) is a morphologically and clinically heterogeneous group of malignant tumors that resemble developing skeletal muscle and is the most common soft-tissue sarcoma in children and adolescents. The most prominent sites involve head and neck structures (~40%), genito-urinary track (~25%), and extremities (~20%). Embryonal (ERMS) and alveolar (ARMS) are the two major RMS subtypes that are distinct in their morphology and genetic make-up. The prognosis for this cancer depends strongly on tumor size, location, staging, and child's age. In general, ERMS has a more favorable outcome, whereas the mortality rate remains high in patients with ARMS, because of its aggressive and metastatic nature. Over the past two decades, researchers have made concerted efforts to delineate genetic and epigenetic changes associated with RMS pathogenesis. These molecular signatures have presented golden opportunities to design targeted therapies for treating this aggressive cancer. This article highlights recent advances in understanding the molecular pathogenesis of RMS, and addresses promising research areas for further exploration.

Indexed as

Rhabdomyosarcoma, AlveolarRhabdomyosarcoma, EmbryonalAdolescentCell DifferentiationCell LineageCell ProliferationChildHumansMolecular Targeted Therapy

Identifiers

PMID21917598
PMCPMC3310752
OpenAlexW2101959302

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.