ArticleGenome biology2011
Expanding whole exome resequencing into non-human primates.
Article in Genome biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 77 citations in OpenAlex.
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- Divergent evolution of hepatocellular carcinoma genomes in chimpanzees and humans.Evolution, medicine, and public health · 2026Article
- Genome-scale evolution in local populations of wild chimpanzees.Scientific reports · 2025Article
- Low hybridization temperatures improve target capture success of invertebrate loci: a case study of leaf-footed bugs (Hemiptera: Coreoidea).Royal Society open science · 2023Article
- Exome sequencing of hepatocellular carcinoma in lemurs identifies potential cancer drivers: A pilot study.Evolution, medicine, and public health · 2022Article
- Cross-species Exon Capture and Whole Exome Sequencing: Application, Utility and Challenges for Genomic Resource Development in Non-model Species.Marine biotechnology (New York, N.Y.) · 2021Article
- Efficiency of whole-exome sequencing in old world and new world primates using human capture reagents.Journal of medical primatology · 2021Article
- Urine as a high-quality source of host genomic DNA from wild populations.Molecular ecology resources · 2021Article
- Genomic targets for high-resolution inference of kinship, ancestry and disease susceptibility in orang-utans (genus: Pongo).BMC genomics · 2020Article
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- MHC genotyping from rhesus macaque exome sequences.Immunogenetics · 2019Article
- Towards population genomics in non-model species with large genomes: a case study of the marine zooplanktonRoyal Society open science · 2019Article
- dCATCH-Seq: improved sequencing of large continuous genomic targets with double-hybridization.BMC genomics · 2017Article
- Efficiency of ddRAD target enriched sequencing across spiny rock lobster species (Palinuridae: Jasus).Scientific reports · 2017Article
- Article
- Improved full-length killer cell immunoglobulin-like receptor transcript discovery in Mauritian cynomolgus macaques.Immunogenetics · 2017Article
- Phylogenomic Insights into Mouse Evolution Using a Pseudoreference Approach.Genome biology and evolution · 2017Article
- Targeted Capture of Complete Coding Regions across Divergent Species.Genome biology and evolution · 2017Article
- Species specific exome probes reveal new insights in positively selected genes in nonhuman primates.Scientific reports · 2016Article
- Purifying selection shapes the coincident SNP distribution of primate coding sequences.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundComplete exome resequencing has the power to greatly expand our understanding of non-human primate genomes. This includes both a better appreciation of the variation that exists in non-human primate model species, but also an improved annotation of their genomes. By developing an understanding of the variation between individuals, non-human primate models of human disease can be better developed. This effort is hindered largely by the lack of comprehensive information on specific non-human primate genetic variation and the costs of generating these data. If the tools that have been developed in humans for complete exome resequencing can be applied to closely related non-human primate species, then these difficulties can be circumvented.
resultsUsing a human whole exome enrichment technique, chimpanzee and rhesus macaque samples were captured alongside a human sample and sequenced using standard next-generation methodologies. The results from the three species were then compared for efficacy. The chimpanzee sample showed similar coverage levels and distributions following exome capture based on the human genome as the human sample. The rhesus macaque sample showed significant coverage in protein-coding sequence but significantly less in untranslated regions. Both chimpanzee and rhesus macaque showed significant numbers of frameshift mutations compared to self-genomes and suggest a need for further annotation.
conclusionsCurrent whole exome resequencing technologies can successfully be used to identify coding-region variation in non-human primates extending into old world monkeys. In addition to identifying variation, whole exome resequencing can aid in better annotation of non-human primate genomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.