ArticleAging cell2011
A model of canine leukocyte telomere dynamics.
Article in Aging cell, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 42 citations in OpenAlex.
- OLD DOG - Validating the dog as an animal model for human aging studies.The Journal of frailty & aging · 2026Article
- Telomere Biology, Erosion, and Age-Related Conditions: Insights from Down Syndrome and Other Telomere-Associated Disorders.Molecular neurobiology · 2025Review
- Involvement of TGF-β, mTOR, and inflammatory mediators in aging alterations during myxomatous mitral valve disease in a canine model.GeroScience · 2025Review
- Impact of trainability on telomere dynamics of pet dogs (Canis lupus familiaris): An explorative study in aging dogs.PloS one · 2025Article
- Telomere Length: Implications for Atherogenesis.Current atherosclerosis reports · 2023Review
- Article
- Review
- Telomere length varies substantially between blood cell types in a reptile.Royal Society open science · 2020Article
- Inactivity and Skeletal Muscle Metabolism: A Vicious Cycle in Old Age.International journal of molecular sciences · 2020Review
- Sex- And tissue-specific differences in telomere length in a reptile.Ecology and evolution · 2019Article
- Oxytocin administration prevents cellular aging caused by social isolation.Psychoneuroendocrinology · 2019Article
- Anthropogenic Effects on Natural Mammalian Populations: Correlation Between Telomere Length and Coal Exposure.Scientific reports · 2019Article
- Exposure to environmental radionuclides associates with tissue-specific impacts on telomerase expression and telomere length.Scientific reports · 2019Article
- Cardiac-Referenced Leukocyte Telomere Length and Outcomes After Cardiovascular Surgery.JACC. Basic to translational science · 2018Article
- Telomere dynamics in wild banded mongooses: Evaluating longitudinal and quasi-longitudinal markers of senescence.Experimental gerontology · 2018Article
- Short Leukocyte Telomere Length Precedes Clinical Expression of Atherosclerosis: The Blood-and-Muscle Model.Circulation research · 2018Article
- Telomere length dynamics in early life: the blood-and-muscle model.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2018Article
- Implications of telomeres and telomerase in endometrial pathology.Human reproduction update · 2017Review
- Method Specific Calibration Corrects for DNA Extraction Method Effects on Relative Telomere Length Measurements by Quantitative PCR.PloS one · 2016Article
- Telomeres shorten in response to oxidative stress in mouse skeletal muscle fibers.The journals of gerontology. Series A, Biological sciences and medical sciences · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Recent studies have found associations of leukocyte telomere length (TL) with diseases of aging and with longevity. However, it is unknown whether birth leukocyte TL or its age-dependent attrition--the two factors that determine leukocyte TL dynamics--explains these associations because acquiring this information entails monitoring individuals over their entire life course. We tested in dogs a model of leukocyte TL dynamics, based on the following premises: (i) TL is synchronized among somatic tissues; (ii) TL in skeletal muscle, which is largely postmitotic, is a measure of TL in early development; and (iii) the difference between TL in leukocytes and muscle (ΔLMTL) is the extent of leukocyte TL shortening since early development. Using this model, we observed in 83 dogs (ages, 4-42 months) no significant change with age in TLs of skeletal muscle and a shorter TL in leukocytes than in skeletal muscle (P<0.0001). Age explained 43% of the variation in ΔLMTL (P<0.00001), but only 6% of the variation in leukocyte TL (P=0.035) among dogs. Accordingly, muscle TL and ΔLMTL provide the two essential factors of leukocyte TL dynamics in the individual dog. When applied to humans, the partition of the contribution of leukocyte TL during early development vs. telomere shortening afterward might provide information about whether the individual's longevity is calibrated to either one or both factors that define leukocyte TL dynamics.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.