Evidence map›Paper›PMID 21917012›Full record

ReviewSeminars in dialysis

Genetic causation of neointimal hyperplasia in hemodialysis vascular access dysfunction.

Timmy Lee, Davinder Wadehra

Open access · bronzeAbstract readReview
In one paragraph

Review in Seminars in dialysis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.0field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Trial
  2. ZHX2 Alleviates Vascular Remodeling and Smooth Muscle Cell Proliferation by Transcriptional Regulation of GADD45G.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Functioning of an arteriovenous fistula requires heme oxygenase-2.American journal of physiology. Renal physiology · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Timmy LeeDepartment of Internal Medicine, Division of Nephrology and Hypertension, University of Cincinnati, Cincinnati, Ohio 45267-0585, USA. timmy.lee@uc.edu
Davinder Wadehra
University of Cincinnati · US

Funding

Novel Biological Markers in Impaired Arteriovenous Fistula MaturationK23DK083528 · NIDDK · UNIVERSITY OF CINCINNATI · PI LEE, TIMMY C · 2009 to 2013
$843k
NIDDK NIH HHS 5K23DK083528-02NIDDK NIH HHS K23 DK083528
6 · The paper itself

Abstract

The major cause of hemodialysis vascular access failure is venous stenosis resulting from neointimal hyperplasia. Genetic factors have been shown to be associated with cardiovascular disease and peripheral vascular disease (PVD) in the general population. Genetic factors may also play an important role in vascular access stenosis and development of neointimal hyperplasia by affecting pathways that lead to inflammation, endothelial function, oxidative stress, and vascular smooth muscle proliferation. This review will discuss the role of genetics in understanding neointimal hyperplasia development in hemodialysis vascular access dysfunction and other disease processes with similar neointimal hyperplasia development such as coronary artery disease and PVD.

Indexed as

Genetic Predisposition to DiseaseArteriovenous Shunt, SurgicalCatheters, IndwellingEquipment FailureGenotypeHumansHyperplasiaKidney Failure, ChronicNeointimaOxidative StressPeripheral Vascular DiseasesPolymorphism, GeneticRenal DialysisRNA, MessengerVascular DiseasesRNA, Messenger

Identifiers

PMID21917012
PMCPMC3965266
OpenAlexW1599379158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.