Trial reportAIDS patient care and STDs2011
Vitamin D status and its association with morbidity including wasting and opportunistic illnesses in HIV-infected women in Tanzania.
Trial report in AIDS patient care and STDs, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Vitamin D in pregnancy: current concepts.Current opinion in obstetrics & gynecology · 2012Pooled it
- Vitamin D3 supplementation during pregnancy and lactation for women living with HIV in Tanzania: A randomized controlled trial.PLoS medicine · 2022Trial
- Trial
- Vitamin-D deficiency impairs CD4+T-cell count recovery rate in HIV-positive adults on highly active antiretroviral therapy: A longitudinal study.Clinical nutrition (Edinburgh, Scotland) · 2016Trial
- HIV, HPV, and oral health in Tanzania: a scoping review.Infectious agents and cancer · 2026Review
- Vitamin D deficiency and oral candidiasis in patients with HIV infection: A case‒control study.BMC infectious diseases · 2024Article
- Prevalence and Causes of Vitamin D Deficiency in a Cohort of Greek HIV-Infected Individuals: A Prospective, Single Center, Observational Study.Current HIV research · 2024Observational
- The Relationship Between Vitamin D and Infections Including COVID-19: Any Hopes?International journal of general medicine · 2021Review
- Continued Interest and Controversy: Vitamin D in HIV.Current HIV/AIDS reports · 2018Review
- The Nutritional Status of HIV-Infected US Adults.Current developments in nutrition · 2017Article
- Vitamin D status in cats with feline immunodeficiency virus.Veterinary medicine and science · 2015Article
- Vitamin D status in Well-Controlled Caucasian HIV Patients in Relation to Inflammatory and Metabolic Markers--A Cross-Sectional Cohort Study in Sweden.Scandinavian journal of immunology · 2015Observational
- Low vitamin D status among pregnant Latin American and Caribbean women with HIV Infection.International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics · 2015Article
- Vitamin D Deficiency in HIV Infection: Not Only a Bone Disorder.BioMed research international · 2015Review
- Vitamin D status and TB treatment outcomes in adult patients in Tanzania: a cohort study.BMJ open · 2013Article
- Vitamin D and insulin resistance in non-diabetic women's interagency HIV study participants.AIDS patient care and STDs · 2013Article
- How important is vitamin D in preventing infections?Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013Review
- Vitamin D status and incidence of pulmonary tuberculosis, opportunistic infections, and wasting among HIV-infected Tanzanian adults initiating antiretroviral therapy.The Journal of infectious diseases · 2013Article
- Interventions to address chronic disease and HIV: strategies to promote exercise and nutrition among HIV-infected individuals.Current HIV/AIDS reports · 2012Review
- Relevance of vitamin D in reproduction.Human reproduction (Oxford, England) · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
Abstract
Vitamin D has a potential role in preventing HIV-related complications, based on its extensive involvement in immune and metabolic function, including preventing osteoporosis and premature cardiovascular disease. However, this association has not been examined in large studies or in resource-limited settings. Vitamin D levels were assessed in 884 HIV-infected pregnant women at enrollment in a trial of multivitamin supplementation (excluding vitamin D) in Tanzania. Information on HIV related complications was recorded during follow-up (median, 70 months). Proportional hazards models and generalized estimating equations were used to assess the relationship of vitamin D status with these outcomes. Women with low vitamin D status (serum 25-hydroxyvitamin D<32 ng/mL) had 43% higher risk of reaching a body mass index (BMI) less than 18 kg/m(2) during the first 2 years of follow-up, compared to women with adequate vitamin D levels (hazard ratio [HR]: 1.43; 95% confidence intervals: [1.03-1.99]). The relationship between continuous vitamin D levels and risk of BMI less than 18 kg/m(2) during follow-up was inverse and linear (p=0.03). Women with low vitamin D levels had significantly higher incidence of acute upper respiratory infections (HR: 1.27 [1.04-1.54]) and thrush (HR: 2.74 [1.29-5.83]) diagnosed during the first 2 years of follow-up. Low vitamin D status was a significant risk factor for wasting and HIV-related complications such as thrush during follow-up in this prospective cohort in Tanzania. If these protective associations are confirmed in randomized trials, vitamin D supplementation could represent a simple and inexpensive method to improve health and quality of life of HIV-infected patients, particularly in resource-limited settings.
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