ArticleThe Journal of organic chemistry2011
Synthesis and reactivity of alkyl-1,1,1-trisphosphonate esters.
Article in The Journal of organic chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- The Hydrolysis of Phosphinates and Phosphonates: A Review.Molecules (Basel, Switzerland) · 2021Review
- Phosphonic acid: preparation and applications.Beilstein journal of organic chemistry · 2017Review
- Synthesis of isoprenoid bisphosphonate ethers through C-P bond formations: Potential inhibitors of geranylgeranyl diphosphate synthase.Beilstein journal of organic chemistry · 2014Article
- Methylidynetrisphosphonates: Promising C1 building block for the design of phosphate mimetics.Beilstein journal of organic chemistry · 2013Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The α-trisphosphonic acid esters provide a unique spatial arrangement of three phosphonate groups and may represent an attractive motif for inhibitors of enzymes that utilize di- or triphosphate substrates. To advance studies of this unique functionality, a general route to alkyl derivatives of the parent system (R = H) has been developed. A set of new α-alkyl-1,1,1-trisphosphonate esters has been prepared through phosphinylation and subsequent oxidation of tetraethyl alkylbisphosphonates, and the reactivity of these new compounds has been studied in representative reactions that afford additional examples of this functionality.
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Registered trials
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