ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2011
Is vitamin D a determinant of muscle mass and strength?
Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 118 citations in OpenAlex.
- Vitamin D supplementation does not enhance resistance training-induced gains in muscle strength and lean body mass in vitamin D deficient young men.European journal of applied physiology · 2021Trial
- No independent or combined effects of vitamin D and conjugated linoleic acids on muscle protein synthesis in older adults: a randomized, double-blind, placebo-controlled clinical trial.The American journal of clinical nutrition · 2020Trial
- The effects of single high-dose or daily low-dosage oral colecalciferol treatment on vitamin D levels and muscle strength in postmenopausal women.BMC endocrine disorders · 2018Trial
- 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 exert distinct effects on human skeletal muscle function and gene expression.PloS one · 2017Trial
- Low vitamin D does not predict statin associated muscle symptoms but is associated with transient increases in muscle damage and pain.Atherosclerosis · 2017Trial
- Vitamin D supplementation does not improve human skeletal muscle contractile properties in insufficient young males.European journal of applied physiology · 2014Trial
- Circulating pro-inflammatory cytokines are elevated and peak power output correlates with 25-hydroxyvitamin D in vitamin D insufficient adults.European journal of applied physiology · 2013Trial
- Efficacy of vitamin D supplementation among persons living with HIV/AIDS in São Paulo city, Brazil.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious DiseasesTrial
- Vitamin D and its receptor in skeletal muscle are associated with muscle disease manifestation, lipid metabolism and physical fitness of patients with myositis.Arthritis research & therapy · 2025Article
- Vitamin D and its relationship to performance and health during a competitive period in elite women's basketball and volleyball players.Physiological reports · 2025Article
- Age but not vitamin D is related to sarcopenia in vitamin D sufficient male elderly in rural China.Scientific reports · 2025Article
- Effect of serum 25-hydroxyvitamin D level on quadriceps strength: a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2024Article
- Genetic Variants, Serum 25-Hydroxyvitamin D Levels, and Sarcopenia: A Mendelian Randomization Analysis.JAMA network open · 2023Article
- Bariatric surgery and calcifediol treatment, Gordian knot of severe-obesity-related comorbidities treatment.Frontiers in endocrinology · 2023Article
- Influences of Vitamin D and Iron Status on Skeletal Muscle Health: A Narrative Review.Nutrients · 2022Review
- Serum 25-hydroxy vitamin D and the risk of low muscle mass in young and middle-aged Korean adults.European journal of endocrinology · 2022Article
- Lack of significant seasonal association between serum 25(OH)D concentration, muscle mass and strength in postmenopausal women from the D-FINES longitudinal study.Journal of nutritional science · 2022Article
- Serum PTH Associated with Malnutrition Determined by Bioelectrical Impedance Technology in Chronic Kidney Disease Patients.International journal of endocrinology · 2022Article
- The Immunomodulatory Function of Vitamin D, with Particular Reference to SARS-CoV-2.Medicina (Kaunas, Lithuania) · 2021Review
- The Impact of Vegan and Vegetarian Diets on Physical Performance and Molecular Signaling in Skeletal Muscle.Nutrients · 2021Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
There remains little consensus on the link between vitamin levels and muscle mass or strength. We therefore investigated the association of serum 25-hydroxyvitamin D (25(OH)D), 1,25-dihydroxyvitamin D (1,25(OH)(2) D), and parathyroid hormone (PTH) levels with skeletal muscle mass and strength. We studied 311 men (mean age, 56 years; range, 23-91 years) and 356 women (mean age, 57 years; range, 21-97 years) representing an age-stratified, random sample of community adults. Multivariate linear regression models were used to examine the association of skeletal muscle mass (by total body dual-energy X-ray absorptiometry) and strength (handgrip force and isometric knee extension moment) with each of 25(OH)D, 1,25(OH)(2) D, and PTH quartiles, adjusted for age, physical activity, fat mass, and season. We found no consistent association between 25(OH)D or PTH and any of our measurements of muscle mass or strength, in either men or women. However, in subjects younger than 65 years, there was a statistically significant association between low 1,25(OH)(2) D levels and low skeletal mass in both men and women and low isometric knee extension moment in women, after adjustment for potential confounders. Modestly low 25(OH)D or high PTH levels may not contribute significantly to sarcopenia or muscle weakness in community adults. The link between low 25(OH)D and increased fall risk reported by others may be due to factors that affect neuromuscular function rather than muscle strength. The association between low 1,25(OH)(2) D and low skeletal mass and low knee extension moment, particularly in younger people, needs further exploration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.