Evidence map›Paper›PMID 21915889›Full record

ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2011

Long non-coding RNA modifies chromatin: epigenetic silencing by long non-coding RNAs.

Alka Saxena, Piero Carninci

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 112 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
112citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

112 citing papers in PubMed, 1 synthesis or guideline pooled it, 209 citations in OpenAlex.

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52 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Alka SaxenaOmics Science Center, RIKEN Yokohama Institute, 1-7-22 Suehiro Cho, Tsurumi Ku, Yokohama, Kanagawa 230-0045, Japan.
Piero Carninci
RIKEN Center for Integrative Medical Sciences · JP

Funding

Comprehensive Characterization and Classification of the Human TranscriptomeU54HG004557 · NHGRI · COLD SPRING HARBOR LABORATORY · PI GINGERAS, THOMAS RAYMOND · 2007 to 2011
$14.5M
NHGRI NIH HHS U54 HG004557
6 · The paper itself

Abstract

Common themes are emerging in the molecular mechanisms of long non-coding RNA-mediated gene repression. Long non-coding RNAs (lncRNAs) participate in targeted gene silencing through chromatin remodelling, nuclear reorganisation, formation of a silencing domain and precise control over the entry of genes into silent compartments. The similarities suggest that these are fundamental processes of transcription regulation governed by lncRNAs. These findings have paved the way for analogous investigations on other lncRNAs and chromatin remodelling enzymes. Here we discuss these common mechanisms and provide our view on other molecules that warrant similar investigations. We also present our concepts on the possible mechanisms that may facilitate the exit of genes from the silencing domains and their potential therapeutic applications. Finally, we point to future areas of research and put forward our recommendations for improvements in resources and applications of existing technologies towards targeted outcomes in this active area of research.

Indexed as

Epigenesis, GeneticGene SilencingAnimalsChromatinChromatin Assembly and DisassemblyGene Expression RegulationGenome, HumanHistonesHumansMethyl-CpG-Binding Protein 2MiceNeoplasmsPromoter Regions, GeneticRett SyndromeRNA Polymerase IIRNA, UntranslatedChromatinHistonesMECP2 protein, humanMecp2 protein, mouseMethyl-CpG-Binding Protein 2RNA Polymerase IIRNA, Untranslated

Identifiers

PMID21915889
PMCPMC3258546
OpenAlexW1520489293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.