ReviewAdvances in experimental medicine and biology2011
Programmed DNA elimination in Tetrahymena: a small RNA-mediated genome surveillance mechanism.
Review in Advances in experimental medicine and biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- The macronuclear genomic landscape withinMicrobial genomics · 2024Article
- Epigenetic transgenerational inheritance of toxicant exposure-specific non-coding RNA in sperm.Environmental epigenetics · 2024Article
- Transcriptome analysis of the binucleate ciliateMolecular biology of the cell · 2023Article
- Current Scenario of Exogenously Induced RNAi for Lepidopteran Agricultural Pest Control: From dsRNA Design to Topical Application.International journal of molecular sciences · 2022Review
- The Evolutionary Significance of RNAi in the Fungal Kingdom.International journal of molecular sciences · 2020Review
- Todos Santos small RNA symposium.RNA biology · 2019Article
- Functional Proteomics of Nuclear Proteins inGenes · 2019Review
- RNA-mediated transgenerational inheritance in ciliates and plants.Chromosoma · 2018Review
- A missense MT-ND5 mutation in differentiated Parkinson Disease cytoplasmic hybrid induces ROS-dependent DNA Damage Response amplified by DROSHA.Scientific reports · 2017Article
- Somatic transposition and meiotically driven elimination of an active helitron family in Pleurotus ostreatus.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017Article
- Phosphorylation of an HP1-like Protein Regulates Heterochromatin Body Assembly for DNA Elimination.Developmental cell · 2015Article
- Transpositional shuffling and quality control in male germ cells to enhance evolution of complex organisms.Annals of the New York Academy of Sciences · 2015Article
- LIA4 encodes a chromoshadow domain protein required for genomewide DNA rearrangements in Tetrahymena thermophila.Eukaryotic cell · 2014Article
- Endogenous siRNAs: regulators of internal affairs.Biochemical Society transactions · 2014Review
- Billions of basepairs of recently expanded, repetitive sequences are eliminated from the somatic genome during copepod development.BMC genomics · 2014Article
- Chromatin-associated ncRNA activities.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- A multitasking Argonaute: exploring the many facets of C. elegans CSR-1.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Review
- Bacterial argonaute samples the transcriptome to identify foreign DNA.Molecular cell · 2013Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
RNA interference (RNAi) was initially discovered as a post-transcriptional gene silencing mechanism in which short RNAs are used to target complementary RNAs for degradation. During the past several years, it has been demonstrated that RNAi-related processes are also involved in transcriptional gene silencing by directing formation of heterochromatin. The dynamic DNA rearrangement during sexual reproduction of the ciliated protozoan Tetrahymena provides an extreme example of RNAi-directed heterochromatin formation. In this process, small RNAs of ∼28-29 nt, which are processed by the Dicer-like protein Dcl1p and are associated with the Argonaute family protein Twi1p, induce heterochromatin formation at complementary genomic sequences by recruiting the histone H3 lysine 9/27 methyltransferase Ezl1p and chromodomain proteins. Eventually these heterochromatinized regions are targeted for DNA elimination. In many eukaryotes, one of the major roles for RNAi-related mechanisms is silencing transposons, and DNA elimination in Tetrahymena is also believed to have evolved as a transposon defense by removing transposon-related sequences from the somatic genome. Because DNA elimination is achieved by the coordinated actions of noncoding RNA transcription, RNA processing, RNA transport, RNA-RNA and RNA-protein interactions, RNA degradation and RNA-directed chromatin modifications, DNA elimination in Tetrahymena is a useful model to study 'RNA infrastructure'.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.