Evidence map›Paper›PMID 21915699›Full record

SynthesisGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2012

A systematic review of spleen and pancreas preservation in extended lymphadenectomy for gastric cancer.

Savtaj S Brar, Rajini Seevaratnam, Roberta Cardoso, Calvin Law, Lucy Helyer, Natalie Coburn

Open access · bronzeAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.

  1. Extent of lymph node dissection for adenocarcinoma of the stomach.The Cochrane database of systematic reviews · 2015
    Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Article
  6. Article
  7. Surgical treatment of gastric cancer: Current status and future directions.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2021
    Article
  8. Article
  9. Review
  10. Review
  11. A Step-Wise Approach to Total Laparoscopic Gastrectomy with Jejunal Pouch Reconstruction: How and Why We Do It.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2016
    Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Should we remove splenic hilus lymph nodes for esophagogastric junction adenocarcinoma?Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2013
    Article
  17. Time trends and disparities in lymphadenectomy for gastrointestinal cancer in the United States: a population-based analysis of 326,243 patients.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2013
    Article
  18. Review
  19. The significance of splenectomy for advanced proximal gastric cancer.International journal of surgical oncology · 2012
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Savtaj S BrarDivision of Surgical Oncology, Sunnybrook Health Sciences Centre, Odette Cancer Centre, Suite T2-60, 2075 Bayview Ave, Toronto, ON, M4N-3M5, Canada.
Rajini Seevaratnam
Roberta Cardoso
Calvin Law
Lucy Helyer
Natalie Coburn
Health Sciences Centre · CADalhousie University · CASunnybrook Health Science Centre · CASunnybrook Research Institute

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe overall prognosis and survival of patients with advanced gastric cancer are generally poor. Extended lymphadenectomy is recommended for patients with advanced gastric cancer; however, splenectomy and distal pancreatectomy performed with an extended lymph node dissection may be associated with increased morbidity and mortality.

methodElectronic literature searches were conducted using Medline, Embase, and the Cochrane Central Register of Controlled Trials from 1 January 1998 to 31 December 2009. Studies on gastric carcinoma investigating extended lymphadenectomy with splenectomy and/or pancreaticosplenectomy that reported data on surgical outcomes or survival were selected.

resultsForty studies were included in this review. Decreased complication rates were demonstrated with spleen preservation in two prospective studies and three retrospective studies, and with pancreas preservation in five retrospective studies. No randomized controlled trial showed survival benefit or detriment for preservation of spleen or pancreas in extended lymphadenectomy. Improved survival was demonstrated with spleen preservation in two prospective and eight retrospective studies, and with pancreas preservation in one prospective and four retrospective studies.

conclusionsPreservation of the spleen and pancreas during extended lymphadenectomy for gastric cancer decreases complications with no clear evidence of improvement or detriment to overall survival.

Indexed as

HumansLymph Node ExcisionPancreasPancreatectomyPrognosisSpleenSplenectomyStomach NeoplasmsSurvival Rate

Identifiers

PMID21915699
OpenAlexW2030435416

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.