ArticleJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology2012
Differential gene expression in the liver of the African lungfish, Protopterus annectens, after 6 days of estivation in air.
Article in Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 42 citations in OpenAlex.
- Comparative transcriptomic evidence of physiological changes and potential relationships in vertebrates under different dormancy states.Zoological research · 2024Article
- Article
- Aestivation in Nature: Physiological Strategies and Evolutionary Adaptations in Hypometabolic States.International journal of molecular sciences · 2023Review
- Aestivation induces widespread transcriptional changes in the African lungfish.Frontiers in genetics · 2023Article
- Genome-wide comparative analysis of DNAJ genes and their co-expression patterns with HSP70s in aestivation of the sea cucumber Apostichopus japonicus.Functional & integrative genomics · 2022Article
- Organ protection by SGLT2 inhibitors: role of metabolic energy and water conservation.Nature reviews. Nephrology · 2021Review
- A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish.Frontiers in immunology · 2019Review
- Molecular characterization of myostatin from the skeletal muscle of the African lungfish, Protopterus annectens, and changes in its mRNA and protein expression levels during three phases of aestivation.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- High salt intake reprioritizes osmolyte and energy metabolism for body fluid conservation.The Journal of clinical investigation · 2017Article
- Interactome of E. piscicida and grouper liver proteins reveals strategies of bacterial infection and host immune response.Scientific reports · 2017Article
- Article
- Molecular characterization of argininosuccinate synthase and argininosuccinate lyase from the liver of the African lungfish Protopterus annectens, and their mRNA expression levels in the liver, kidney, brain and skeletal muscle during aestivation.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
- Brain Na+/K+-ATPase α-subunit isoforms and aestivation in the African lungfish, Protopterus annectens.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
- Article
- Hepatic carbamoyl phosphate synthetase (CPS) I and urea contents in the hylid tree frog, Litoria caerulea: transition from CPS III to CPS I.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2012Article
- Molecular characterization and mRNA expression of carbamoyl phosphate synthetase III in the liver of the African lungfish, Protopterus annectens, during aestivation or exposure to ammonia.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2012Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to identify estivation-specific gene clusters through the determination of differential gene expressions in the liver of Protopterus annectens after 6 days of estivation in a mucus cocoon in air (normoxia) using suppression subtractive hybridization polymerase chain reaction. Our results demonstrated that 6 days of estivation in normoxia led to up-regulation of mRNA expressions of several genes related to urea synthesis, including carbamoyl phosphate synthetase (Cps), argininosuccinate synthetase and glutamine synthetase. They indicate that increased urea synthesis, despite being energy-intensive, is an important adaptive response of estivation. They also offer indirect support to the proposition that urea synthesis in this lungfish involved a Cps that uses glutamine as a substrate. In addition, up- or down-regulation of several gene clusters occurred in the liver of P. annectens after 6 days of estivation in normoxia. These estivation-specific genes were involved in the prevention of clot formation, activation of the lectin pathway for complement activation, conservation of minerals (e.g. iron and copper) and increased production of hemoglobin beta. Since there were up- and down-regulation of mRNA expressions of genes related to ribosomal proteins and translational elongation factors, there could be simultaneous increases in protein degradation and protein synthesis during the first 6 days (the induction phase) of estivation, confirming the importance of reconstruction of protein structures in preparation for the maintenance phase of estivation.
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