ArticleClinics (Sao Paulo, Brazil)2011
Effects of mycophenolate sodium on mucociliary clearance using a bronchial section and anastomosis rodent model.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Bronchiectasis in renal transplant patients: a narrative review.BMJ open respiratory research · 2026Review
- Hypogammaglobulinemia in pediatric kidney transplant recipients.Pediatric nephrology (Berlin, Germany) · 2023Article
- Basiliximab Does Not Impair Airway Mucociliary Clearance of Rats.Inflammation · 2022Article
- The effects of individually ventilated cages on the respiratory systems of male and female Wistar rats from birth until adulthood.Clinics (Sao Paulo, Brazil) · 2017Article
- Building a Lung Transplant Program.Clinics (Sao Paulo, Brazil) · 2015Article
- Bronchiectasis diagnosed after renal transplantation: a retrospective multicenter study.BMC pulmonary medicine · 2015Article
- Review
- Pneumological research in Clinics.Clinics (Sao Paulo, Brazil) · 2012Article
- The effects on mucociliary clearance of prednisone associated with bronchial section.Clinics (Sao Paulo, Brazil) · 2012Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo study the effects of mycophenolate sodium on mucociliary clearance.
introductionMycophenolate is one of the most commonly used immunosuppressive drugs in lung transplantation. Although its pharmacokinetic properties are well defined, its side effects on mucociliary clearance have not yet been studied.
methodsSixty rats were subjected to left bronchial section and anastomosis. The right bronchus was used as a control. After surgery, the rats were assigned to two groups based on whether they received saline solution (n = 30) or mycophenolate sodium (n = 30). After 7, 15, or 30 days of treatment, 10 animals from each group were sacrificed, and in vitro mucus transportability, in situ mucociliary transport velocity and ciliary beat frequency were measured.
resultsThe analysis of mucus transportability revealed that neither mycophenolate nor bronchial section altered any transportability related property for up to 30 days of treatment after surgery (p>0.05). With regard to ciliary beat frequency, the operated left bronchi from the mycophenolate group showed a significant decrease on post-surgical day 30 (p = 0.003). In addition, we found a significant reduction in the in situ mucociliary transport velocity in the mycophenolate-treated group (p = 0.0001). DISCUSSION: These data add important information regarding mucociliary clearance dysfunction following mycophenolate therapy and suggest that mycophenolate might contribute to the high incidence of respiratory tract infections in lung transplant patients. Further studies are needed to investigate the combined action of mycophenolate with other immunosuppressive drugs and to establish methods to protect and recover mucociliary clearance, an important airway defense mechanism.
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