ArticleClinics (Sao Paulo, Brazil)2011
Effects of diabetes on myocardial capillary density and serum angiogenesis biomarkers in male rats.
Article in Clinics (Sao Paulo, Brazil), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Neutrophil extracellular traps and peptidylarginine deiminase 4-mediated inflammasome activation link diabetes to cardiorenal injury and heart failure.European heart journal · 2025Article
- Diminished Circulating Levels of Angiogenic Factors and Rage Ligands in Helminth-Diabetes Comorbidity and Reversal Following Anthelmintic Treatment.The Journal of infectious diseases · 2021Article
- Treadmill Running Changes Endothelial Lipase Expression: Insights from Gene and Protein Analysis in Various Striated Muscle Tissues and Serum.Biomolecules · 2021Article
- Systemic elucidation on the potential bioactive compounds and hypoglycemic mechanism of Polygonum multiflorum based on network pharmacology.Chinese medicine · 2020Article
- The effect of 8 weeks of high-intensity interval training and moderate-intensity continuous training on cardiac angiogenesis factor in diabetic male rats.Journal of physiology and biochemistry · 2020Article
- Serum IL-6 and sIL-6R in type 2 diabetes contribute to impaired capillary-like network formation.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Article
- The Effect of Garlic and Voluntary Exercise on Cardiac Angiogenesis in Diabetes: The Role of MiR-126 and MiR-210.Arquivos brasileiros de cardiologia · 2019Article
- Cardiac and renal fibrosis and oxidative stress balance in lipopolysaccharide-induced inflammation in male rats.ARYA atherosclerosis · 2018Article
- Testosterone and Voluntary Exercise, Alone or Together Increase Cardiac Activation of AKT and ERK1/2 in Diabetic Rats.Arquivos brasileiros de cardiologia · 2016Article
- Myocardial capillary density after neuropeptide Y antagonist administration in normal and high-fat diet C57BL6 mice.Advanced biomedical research · 2016Article
- Histone deacetylase (HDAC) inhibition improves myocardial function and prevents cardiac remodeling in diabetic mice.Cardiovascular diabetology · 2015Article
- Histomorphometric evaluation of the small coronary arteries in rats exposed to industrial noise.International journal of molecular sciences · 2015Article
- Glutaredoxin-1 up-regulation induces soluble vascular endothelial growth factor receptor 1, attenuating post-ischemia limb revascularization.The Journal of biological chemistry · 2014Article
- Treadmill Exercise Training Improves Vascular Endothelial Growth Factor Expression in the Cardiac Muscle of Type I Diabetic Rats.Cardiology research · 2014Article
- The relationship between inflammatory markers, angiogenesis, and obesity.ARYA atherosclerosis · 2013Article
- Cardiovascular research in CLINICS.Clinics (Sao Paulo, Brazil) · 2013Article
- Stereological study of the diabetic heart of male rats.Laboratory animal research · 2013Article
- Changes of serum angiogenic factors concentrations in patients with diabetes and unstable angina pectoris.Cardiovascular diabetology · 2013Article
- Imbalance of angiogenesis in diabetic complications: the mechanisms.International journal of preventive medicine · 2012Article
- A review on angiogenesis and its assays.Iranian journal of basic medical sciences · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionCardiovascular disease is one of the main causes of mortality and morbidity in diabetic patients. This study evaluated the effects of diabetes on myocardial capillary density and several serum angiogenic factors including nitric oxide, vascular endothelial growth factor, and soluble vascular endothelial growth factor receptors.
methodsTwelve male rats were divided into two groups: control and diabetic (n = 6 each). Diabetes was induced with a single dose of streptozotocin (50 mg/kg). After 21 days, capillary density in the myocardial tissue was evaluated using immunohistochemical staining and is reported as capillaries per mm². Blood samples were collected before and after the induction of diabetes.
resultsIn the diabetic group, serum nitric oxide and soluble vascular endothelial growth factor receptor 2 concentrations were lower than the levels in the control group, while the level of soluble vascular endothelial growth factor receptor 1 was significantly higher. There was no significant change in the serum vascular endothelial growth factor concentration between the diabetic and control groups; however, the ratio of vascular endothelial growth factor to vascular endothelial growth factor receptor 1 was significantly lower in the diabetic animals. The myocardial capillary density was also lower in the diabetic group compared with the control group (1549 ± 161 vs. 2156 ± 202/mm², respectively).
conclusionReduced serum nitric oxide and vascular endothelial growth factor receptor 2 levels, increased serum vascular endothelial growth factor receptor 1 levels and a lower vascular endothelial growth factor to vascular endothelial growth factor receptor 1 ratio may be responsible for the decreased myocardial capillary density in diabetic rats.
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