Evidence map›Paper›PMID 21915339›Full record

ArticlePloS one2011

Genetic analysis of a novel human adenovirus with a serologically unique hexon and a recombinant fiber gene.

Elizabeth B Liu, Leonardo Ferreyra, Stephen L Fischer, Jorge V Pavan, Silvia V Nates, Nolan Ryan Hudson, Damaris Tirado, David W Dyer, James Chodosh, Donald Seto and 1 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
5.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Antiviral activity ofFrontiers in pharmacology · 2025
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  14. [Genotypes of adenoviruses in infants and young children with diarrhea].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2016
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Elizabeth B LiuDepartment of Bioinformatics and Computational Biology, George Mason University, Manassas, Virginia, United States of America.
Leonardo Ferreyra
Stephen L Fischer
Jorge V Pavan
Silvia V Nates
Nolan Ryan Hudson
Damaris Tirado
David W Dyer
James Chodosh
Donald Seto
Morris S Jones
Universidad Nacional de Córdoba · ARDavid Grant USAF Medical Center · USGeorge Mason University · USCalifornia Department of Public Health · USMassachusetts Eye and Ear Infirmary · USUniversity of Oklahoma Health Sciences Center · US

Funding

P30 Core Grant for Vision ResearchP30EY014104 · NEI · MASSACHUSETTS EYE AND EAR INFIRMARY · PI Eric A Pierce · 2002 to 2026
$15.1M
Immunopathogenesis of Adenovirus KeratitisR01EY013124 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI James Chodosh, Jaya Rajaiya · 2001 to 2026
$10.8M
NEI NIH HHS P30 EY014104NEI NIH HHS P30EY014104NEI NIH HHS R01 EY013124NEI NIH HHS R01EY013124
6 · The paper itself

Abstract

In February of 1996 a human adenovirus (formerly known as Ad-Cor-96-487) was isolated from the stool of an AIDS patient who presented with severe chronic diarrhea. To characterize this apparently novel pathogen of potential public health significance, the complete genome of this adenovirus was sequenced to elucidate its origin. Bioinformatic and phylogenetic analyses of this genome demonstrate that this virus, heretofore referred to as HAdV-D58, contains a novel hexon gene as well as a recombinant fiber gene. In addition, serological analysis demonstrated that HAdV-D58 has a different neutralization profile than all previously characterized HAdVs. Bootscan analysis of the HAdV-D58 fiber gene strongly suggests one recombination event.

Indexed as

Adenoviruses, HumanCapsid ProteinsComputational BiologyGenome, ViralHumansPhylogenyRecombinant ProteinsCapsid Proteinshexon capsid protein, AdenovirusRecombinant Proteins

Identifiers

PMID21915339
PMCPMC3168504
OpenAlexW1987139425

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.