ArticlePloS one2011
Cardiac remodeling in fish: strategies to maintain heart function during temperature Change.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 140 citations in OpenAlex.
- Leveraging environmental information for enhanced prediction of cardiac readmissions.iScience · 2025Article
- Integrated response of the zebrafish (Danio rerio) cardiovascular system to hypoxia acclimation.The Journal of experimental biology · 2025Article
- Transcriptome remodelling and changes in growth and cardiometabolic phenotype result following Grb10a knockdown in the early life of the zebrafish.Cellular and molecular life sciences : CMLS · 2025Article
- Cold-induced fibrosis and metabolic remodeling in the turtle (Trachemys scripta) ventricle.Acta physiologica (Oxford, England) · 2025Article
- Prior thermal acclimation gives White Sturgeon a fin up dealing with low oxygen.Conservation physiology · 2025Article
- Molecular regulation of reversible cardiac remodeling: lessons from species with extreme physiological adaptations.The Journal of experimental biology · 2024Review
- Importance of environmental signals for cardiac morphological development in Atlantic salmon.The Journal of experimental biology · 2024Article
- Comparative analysis of ventricular stiffness across species.Physiological reports · 2024Review
- A Conserved Mechanism of Cardiac Hypertrophy Regression through FoxO1.bioRxiv : the preprint server for biology · 2024Article
- Long-term stress induced cortisol downregulation, growth reduction and cardiac remodeling in Atlantic salmon.The Journal of experimental biology · 2023Article
- Thermal tolerance and vulnerability to warming differ between populations of wild Oncorhynchus mykiss near the species' southern range limit.Scientific reports · 2023Article
- Cardiorespiratory physiology and swimming capacity of Atlantic salmon (Salmo salar) at cold temperatures.The Journal of experimental biology · 2023Article
- Trans-Acting Genotypes Associated with mRNA Expression Affect Metabolic and Thermal Tolerance Traits.Genome biology and evolution · 2023Article
- Seasonal temperatures in South Eleuthera, The Bahamas, have considerable impacts on the cardiorespiratory function and swimming performance of Nassau grouper (Conservation physiology · 2023Article
- Body size dictates physiological and behavioural responses to hypoxia and elevated water temperatures in Murray cod (Conservation physiology · 2023Article
- Anguimorpha as a model group for studying the comparative heart morphology among Lepidosauria: Evolutionary window on the ventricular septation.Ecology and evolution · 2022Article
- Rapid cardiac thermal acclimation in wild anadromous Arctic char (Salvelinus alpinus).The Journal of experimental biology · 2022Article
- Proteomic analysis of temperature-dependent developmental plasticity within the ventricle of juvenile Atlantic salmon (Current research in physiology · 2022Article
- Seasonal changes of electrophysiological heterogeneities in the rainbow trout ventricular myocardium.Current research in physiology · 2022Article
- Effect of thermal variation on the cardiac thermal limits of a eurythermal marine teleost (Current research in physiology · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Rainbow trout remain active in waters that seasonally change between 4°C and 20°C. To explore how these fish are able to maintain cardiac function over this temperature range we characterized changes in cardiac morphology, contractile function, and the expression of contractile proteins in trout following acclimation to 4°C (cold), 12°C (control), and 17°C (warm). The relative ventricular mass (RVM) of the cold acclimated male fish was significantly greater than that of males in the control group. In addition, the compact myocardium of the cold acclimated male hearts was thinner compared to controls while the amount of spongy myocardium was found to have increased. Cold acclimation also caused an increase in connective tissue content, as well as muscle bundle area in the spongy myocardium of the male fish. Conversely, warm acclimation of male fish caused an increase in the thickness of the compact myocardium and a decrease in the amount of spongy myocardium. There was also a decrease in connective tissue content in both myocardial layers. In contrast, there was no change in the RVM or connective tissue content in the hearts of female trout with warm or cold acclimation. Cold acclimation also caused a 50% increase in the maximal rate of cardiac AM Mg(2+)-ATPase but did not influence the Ca(2+) sensitivity of this enzyme. To identify a mechanism for this change we utilized two-dimensional difference gel electrophoresis to characterize changes in the cardiac contractile proteins. Cold acclimation caused subtle changes in the phosphorylation state of the slow skeletal isoform of troponin T found in the heart, as well as of myosin binding protein C. These results demonstrate that acclimation of trout to warm and cold temperatures has opposing effects on cardiac morphology and tissue composition and that this results in distinct warm and cold cardiac phenotypes.
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