ArticlePloS one2011
Adenomatous polyposis coli regulates axon arborization and cytoskeleton organization via its N-terminus.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 27 citations in OpenAlex.
- APC orchestrates microtubule dynamics by acting as a positive regulator of KIF2A and a negative regulator of CLASPs.Cell insight · 2025Article
- Branched actin networks are assembled on microtubules by adenomatous polyposis coli for targeted membrane protrusion.The Journal of cell biology · 2020Article
- Molecular mechanisms behind mRNA localization in axons.Open biology · 2020Review
- Microtubule plus-end tracking Adenopolyposis Coli negatively regulates proplatelet formation.Scientific reports · 2018Article
- Social Stimulus Causes Aberrant Activation of the Medial Prefrontal Cortex in a Mouse Model With Autism-Like Behaviors.Frontiers in synaptic neuroscience · 2018Article
- It takes a village to raise a branch: Cellular mechanisms of the initiation of axon collateral branches.Molecular and cellular neurosciences · 2017Review
- Actin filament-microtubule interactions in axon initiation and branching.Brain research bulletin · 2016Review
- Tumour Suppressor Adenomatous Polyposis Coli (APC) localisation is regulated by both Kinesin-1 and Kinesin-2.Scientific reports · 2016Article
- Microtubule plus-end tracking proteins in neuronal development.Cellular and molecular life sciences : CMLS · 2016Review
- Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development.International review of cell and molecular biology · 2016Review
- Differential regulation of microtubule severing by APC underlies distinct patterns of projection neuron and interneuron migration.Developmental cell · 2014Article
- MACF1 regulates the migration of pyramidal neurons via microtubule dynamics and GSK-3 signaling.Developmental biology · 2014Article
- Subcellular transcriptome alterations in a cell culture model of spinal muscular atrophy point to widespread defects in axonal growth and presynaptic differentiation.RNA (New York, N.Y.) · 2014Article
- Article
- Branch management: mechanisms of axon branching in the developing vertebrate CNS.Nature reviews. Neuroscience · 2014Review
- Cell biology in neuroscience: Cellular and molecular mechanisms underlying axon formation, growth, and branching.The Journal of cell biology · 2013Review
- Adenomatous polyposis coli regulates oligodendroglial development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The cytoskeleton and neurite initiation.BioarchitectureReview
- Adenomatous Polyposis Coli (APC) in cell migration.European journal of cell biologyReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
Conditional deletion of APC leads to marked disruption of cortical development and to excessive axonal branching of cortical neurons. However, little is known about the cell biological basis of this neuronal morphological regulation. Here we show that APC deficient cortical neuronal growth cones exhibit marked disruption of both microtubule and actin cytoskeleton. Functional analysis of the different APC domains revealed that axonal branches do not result from stabilized β-catenin, and that the C-terminus of APC containing microtubule regulatory domains only partially rescues the branching phenotype. Surprisingly, the N-terminus of APC containing the oligomerization domain and the armadillo repeats completely rescues the branching and cytoskeletal abnormalities. Our data indicate that APC is required for appropriate axon morphological development and that the N-terminus of APC is important for regulation of the neuronal cytoskeleton.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.