ArticleNature communications2011
Plasmonic substrates for multiplexed protein microarrays with femtomolar sensitivity and broad dynamic range.
Article in Nature communications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
68 citing papers in PubMed.
- Do-it-yourself protein arrays as high-throughput immunoassays enabled by confined droplets on patterned plasmonic chips.Nature communications · 2026Article
- Rapid, Tunable, and Scalable Patterning of Plasmonic Films for Biosensing Applications.ACS applied materials & interfaces · 2025Article
- A SARS-CoV-2 vaccine on an NIR-II/SWIR emitting nanoparticle platform.Science advances · 2025Article
- High-Throughput Approaches to Engineer Fluorescent Nanosensors.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Plasmonic biosensors and actuators for integrated point-of-care diagnostics.Npj biosensing · 2025Review
- Plasmonic nanoparticle sensors: current progress, challenges, and future prospects.Nanoscale horizons · 2024Review
- Plasmonic nano-aperture label-free imaging of single small extracellular vesicles for cancer detection.Communications medicine · 2024Article
- Plasmonic Au@Ag Core-Shell Nanoisland Film for Photothermal Inactivation and Surface-Enhanced Raman Scattering Detection of Bacteria.Nanomaterials (Basel, Switzerland) · 2024Article
- Self-Confined Dewetting Mechanism in Wafer-Scale Patterning of Gold Nanoparticle Arrays with Strong Surface Lattice Resonance for Plasmonic Sensing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies.Advanced materials (Deerfield Beach, Fla.) · 2023Review
- Dielectric metasurfaces for next-generation optical biosensing: a comparison with plasmonic sensing.Nanotechnology · 2023Review
- Multiplexed evaluation of immunity against SARS-CoV-2 variants using surface enhanced fluorescence from a nanostructured plasmonic chip.Journal of nanobiotechnology · 2022Article
- Quantitative and sensitive detection of alpha fetoprotein in serum by a plasmonic sensor.Nanophotonics (Berlin, Germany) · 2022Article
- Plasmonically-enhanced competitive assay for ultrasensitive and multiplexed detection of small molecules.Biosensors & bioelectronics · 2022Article
- Plasmonic nanosensors for point-of-care biomarker detection.Materials today. Bio · 2022Review
- Toward the Development of Rapid, Specific, and Sensitive Microfluidic Sensors: A Comprehensive Device Blueprint.JACS Au · 2021Review
- Plasmonic Gold Nanoisland Film for Bacterial Theranostics.Nanomaterials (Basel, Switzerland) · 2021Article
- Bioinspired nanoantennas for opsin sensitization in optogenetic applications: a theoretical investigation.Multifunctional materials · 2021Article
- A straightforward and sensitive "ON-OFF" fluorescence immunoassay based on silicon-assisted surface enhanced fluorescence.RSC advances · 2021Article
- Monolithic integration of nanorod arrays on microfluidic chips for fast and sensitive one-step immunoassays.Microsystems & nanoengineering · 2021Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Protein chips are widely used for high-throughput proteomic analysis, but to date, the low sensitivity and narrow dynamic range have limited their capabilities in diagnostics and proteomics. Here we present protein microarrays on a novel nanostructured, plasmonic gold film with near-infrared fluorescence enhancement of up to 100-fold, extending the dynamic range of protein detection by three orders of magnitude towards the fM regime. We employ plasmonic protein microarrays for the early detection of a cancer biomarker, carcinoembryonic antigen, in the sera of mice bearing a xenograft tumour model. Further, we demonstrate a multiplexed autoantigen array for human autoantibodies implicated in a range of autoimmune diseases with superior signal-to-noise ratios and broader dynamic range compared with commercial nitrocellulose and glass substrates. The high sensitivity, broad dynamic range and easy adaptability of plasmonic protein chips presents new opportunities in proteomic research and diagnostics applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.