ArticleProceedings of the National Academy of Sciences of the United States of America2011
Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Proliferation-dependent adipogenic differentiation of progenitor cells in rat coronary artery explants.Stem cell research & therapy · 2026Article
- Netrin-1 disrupt high-fat-diet-induced adipogenesis via the PPARγ and Wnt/β-catenin signaling pathways.Communications biology · 2026Article
- Reduced Growth and Inflammation in Lrp5Journal of cellular and molecular medicine · 2025Article
- Mechanical Cell Reprogramming on Tissue-Mimicking Hydrogels for Cancer Cell Transdifferentiation.Research (Washington, D.C.) · 2025Article
- Transcription factor PATZ1 promotes adipogenesis by controlling promoter regulatory loci of adipogenic factors.Nature communications · 2024Article
- Review
- Fibro-adipogenic progenitors in physiological adipogenesis and intermuscular adipose tissue remodeling.Molecular aspects of medicine · 2024Review
- Control of murine brown adipocyte development by GATA6.Developmental cell · 2023Article
- Wnt/β-catenin signaling regulates adipose tissue lipogenesis and adipocyte-specific loss is rigorously defended by neighboring stromal-vascular cells.Molecular metabolism · 2020Article
- Novel Insights into Adipogenesis from the Perspective of Transcriptional and RNA N6-Methyladenosine-Mediated Post-Transcriptional Regulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Review
- Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction.Molecular metabolism · 2020Article
- MLL3/MLL4-Associated PAGR1 Regulates Adipogenesis by Controlling Induction of C/EBPβ and C/EBPδ.Molecular and cellular biology · 2020Article
- Identification of eQTLs associated with lipid metabolism in Longissimus dorsi muscle of pigs with different genetic backgrounds.Scientific reports · 2020Article
- Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits.Nature communications · 2020Article
- Transient Delivery of A-C/EBP Protein Perturbs Differentiation of 3T3-L1 Cells and Induces Preadipocyte Marker Genes.Frontiers in molecular biosciences · 2020Article
- Modelling the gene expression and the DNA-binding in the 3T3-L1 differentiating adipocytes.Adipocyte · 2019Article
- LincRNA H19 protects from dietary obesity by constraining expression of monoallelic genes in brown fat.Nature communications · 2018Article
- Identification of transcription factors potentially involved in human adipogenesis in vitro.Molecular genetics & genomic medicine · 2017Article
- Epigenetic programming of Dnmt3a mediated by AP2α is required for granting preadipocyte the ability to differentiate.Cell death & disease · 2016Article
- Identification of zinc finger protein Bcl6 as a novel regulator of early adipose commitment.Open biology · 2016Article
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Authors and funding
8 authors.
Funding
Abstract
The identification of factors that define adipocyte precursor potential has important implications for obesity. Preadipocytes are fibroblastoid cells committed to becoming round lipid-laden adipocytes. In vitro, this differentiation process is facilitated by confluency, followed by adipogenic stimuli. During adipogenesis, a large number of cytostructural genes are repressed before adipocyte gene induction. Here we report that the transcriptional repressor transcription factor 7-like 1 (TCF7L1) binds and directly regulates the expression of cell structure genes. Depletion of TCF7L1 inhibits differentiation, because TCF7L1 indirectly induces the adipogenic transcription factor peroxisome proliferator-activated receptor γ in a manner that can be replaced by inhibition of myosin II activity. TCF7L1 is induced by cell contact in adipogenic cell lines, and ectopic expression of TCF7L1 alleviates the confluency requirement for adipocytic differentiation of precursor cells. In contrast, TCF7L1 is not induced during confluency of non-adipogenic fibroblasts, and, remarkably, forced expression of TCF7L1 is sufficient to commit non-adipogenic fibroblasts to an adipogenic fate. These results establish TCF7L1 as a transcriptional hub coordinating cell-cell contact with the transcriptional repression required for adipogenic competency.
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