ArticlePhysiological genomics2011
Multistate proteomics analysis reveals novel strategies used by a hibernator to precondition the heart and conserve ATP for winter heterothermy.
Article in Physiological genomics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Proteomic Mechanisms of Hepatic- and Cardio-Protection of a Food-Hoarding Hibernator, Tamias sibiricus.Integrative zoology · 2026Article
- Proteomic Identification of Seasonally Expressed Proteins Contributing to Heart Function and the Avoidance of Skeletal Muscle Disuse Atrophy in a Hibernating Mammal.Journal of proteome research · 2024Article
- Molecular strategies used by hibernators: Potential therapeutic directions for ischemia reperfusion injury and preservation of human donor organs.Transplantation reviews (Orlando, Fla.) · 2020Review
- Article
- Hibernation in bats (Mammalia: Chiroptera) did not evolve through positive selection of leptin.Ecology and evolution · 2018Article
- Molecular Basis of White Adipose Tissue Remodeling That Precedes and Coincides With Hibernation in the Syrian Hamster, a Food-Storing Hibernator.Frontiers in physiology · 2018Article
- Comparative tissue transcriptomics highlights dynamic differences among tissues but conserved metabolic transcript prioritization in preparation for arousal from torpor.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Hibernation reduces cellular damage caused by warm hepatic ischemia-reperfusion in ground squirrels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2017Article
- Seasonal and post-trauma remodeling in cone-dominant ground squirrel retina.Experimental eye research · 2016Review
- Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia-Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats.Anesthesiology · 2016Article
- Response of the JAK-STAT pathway to mammalian hibernation in 13-lined ground squirrel striated muscle.Molecular and cellular biochemistry · 2016Article
- HSP90AB1: Helping the good and the bad.Gene · 2016Review
- Plasma proteomic analysis of active and torpid greater mouse-eared bats (Myotis myotis).Scientific reports · 2015Article
- Proteomics approaches shed new light on hibernation physiology.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2015Review
- The Recovery of Hibernating Hearts Lies on a Spectrum: from Bears in Nature to Patients with Coronary Artery Disease.Journal of cardiovascular translational research · 2015Review
- Myocardial ischemic protection in natural mammalian hibernation.Basic research in cardiology · 2015Article
- Gene expression changes controlling distinct adaptations in the heart and skeletal muscle of a hibernating mammal.Physiological genomics · 2015Article
- Metabolic changes associated with the long winter fast dominate the liver proteome in 13-lined ground squirrels.Physiological genomics · 2014Article
- Substrate-specific changes in mitochondrial respiration in skeletal and cardiac muscle of hibernating thirteen-lined ground squirrels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2014Article
- Intrinsic circannual regulation of brown adipose tissue form and function in tune with hibernation.American journal of physiology. Endocrinology and metabolism · 2014Article
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Authors and funding
6 authors.
Funding
Abstract
The hibernator's heart functions continuously and avoids damage across the wide temperature range of winter heterothermy. To define the molecular basis of this phenotype, we quantified proteomic changes in the 13-lined ground squirrel heart among eight distinct physiological states encompassing the hibernator's year. Unsupervised clustering revealed a prominent seasonal separation between the summer homeotherms and winter heterotherms, whereas within-season state separation was limited. Further, animals torpid in the fall were intermediate to summer and winter, consistent with the transitional nature of this phase. A seasonal analysis revealed that the relative abundances of protein spots were mainly winter-increased. The winter-elevated proteins were involved in fatty acid catabolism and protein folding, whereas the winter-depleted proteins included those that degrade branched-chain amino acids. To identify further state-dependent changes, protein spots were re-evaluated with respect to specific physiological state, confirming the predominance of seasonal differences. Additionally, chaperone and heat shock proteins increased in winter, including HSPA4, HSPB6, and HSP90AB1, which have known roles in protecting against ischemia-reperfusion injury and apoptosis. The most significant and greatest fold change observed was a disappearance of phospho-cofilin 2 at low body temperature, likely a strategy to preserve ATP. The robust summer-to-winter seasonal proteomic shift implies that a winter-protected state is orchestrated before prolonged torpor ensues. Additionally, the general preservation of the proteome during winter hibernation and an increase of stress response proteins, together with dephosphorylation of cofilin 2, highlight the importance of ATP-conserving mechanisms for winter cardioprotection.
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