SynthesisBritish journal of pharmacology2012
Predicting the emetic liability of novel chemical entities: a comparative study.
Synthesis in British journal of pharmacology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.
- The role of the parasympathetic nervous system in visually induced motion sickness: systematic review and meta-analysis.Experimental brain research · 2014Pooled it
- Evaluating proxies for motion sickness in rodent.IBRO neuroscience reports · 2023Article
- Justification for species selection for pharmaceutical toxicity studies.Toxicology research · 2020Article
- Antiemetic Effects of Cannabinoid Agonists in Nonhuman Primates.The Journal of pharmacology and experimental therapeutics · 2020Article
- Type A Trichothecene Diacetoxyscirpenol-Induced Emesis Corresponds to Secretion of Peptide YY and Serotonin in Mink.Toxins · 2020Article
- Can Cephalopods Vomit? Hypothesis Based on a Review of Circumstantial Evidence and Preliminary Experimental Observations.Frontiers in physiology · 2020Article
- Prokinetic effects of the neurokinin NK2 receptor agonist [LysNeuropeptides · 2019Article
- An assay of drug-induced emesis in the squirrel monkey (Saimiri sciureus).Journal of medical primatology · 2019Article
- Phosphodiesterase 1b (PDE1B) Regulates Spatial and Contextual Memory in Hippocampus.Frontiers in molecular neuroscience · 2019Article
- Article
- A History of Drug Discovery for Treatment of Nausea and Vomiting and the Implications for Future Research.Frontiers in pharmacology · 2018Review
- Appropriateness to set a group health based guidance value for nivalenol and its modified forms.EFSA journal. European Food Safety Authority · 2017Article
- Appropriateness to set a group health based guidance value for T2 and HT2 toxin and its modified forms.EFSA journal. European Food Safety Authority · 2017Article
- The multifactorial role of the 3Rs in shifting the harm-benefit analysis in animal models of disease.European journal of pharmacology · 2015Article
- Pioneering better science through the 3Rs: an introduction to the national centre for the replacement, refinement, and reduction of animals in research (NC3Rs).Journal of the American Association for Laboratory Animal Science : JAALAS · 2015Article
- Differential hypoglycaemic, anorectic, autonomic and emetic effects of the glucagon-like peptide receptor agonist, exendin-4, in the conscious telemetered ferret.Journal of translational medicine · 2014Article
- Assessment of low-dose cisplatin as a model of nausea and emesis in beagle dogs, potential for repeated administration.Experimental brain research · 2014Article
- Peptide YY3-36 and 5-hydroxytryptamine mediate emesis induction by trichothecene deoxynivalenol (vomitoxin).Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Evaluation of chemically diverse 5-HT₂c receptor agonists on behaviours motivated by food and nicotine and on side effect profiles.Psychopharmacology · 2013Article
- Comparison of emetic potencies of the 8-ketotrichothecenes deoxynivalenol, 15-acetyldeoxynivalenol, 3-acetyldeoxynivalenol, fusarenon X, and nivalenol.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeEmesis is a multi-system reflex, which is usually investigated using in vivo models. The aim of the study is to compare the response induced by emetic compounds across species and investigate whether dogs, ferrets and rats are all similarly predictive of humans. EXPERIMENTAL APPROACH: A systematic review was carried out and relevant publications were identified from PubMed. The search was restricted to four species (human, dog, ferret, rat) and ten compounds representative of various mechanisms of emesis induction (apomorphine, cisplatin, cholecystokinin octapeptide, copper sulphate, cyclophosphamide, ipecacuanha, lithium chloride, morphine, nicotine, rolipram). KEY
results1046 publications were reviewed, and 311 were included, the main reason for exclusion was the lack of quantitative data. Emetic or pica data were extracted as incidence, intensity or latency. All three animal species identified emetic liability but interspecies differences for dose sensitivity were detected. CONCLUSIONS AND IMPLICATION: These results suggest that emetic liability can be reliably identified in a common laboratory species such as the rat. However, to evaluate the characteristics of the emetic response, no animal species is a universal predictor of emetic liability and the choice of species should be an informed decision based on the type of compound investigated. Limitations relating to the conduct and reporting of emesis studies were identified, the main ones being the lack of comparable outcome measures between human and animal data, and the limited availability of human data in the public domain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.