Evidence map›Paper›PMID 21913711›Full record

ArticleJournal of the American Chemical Society2011

A multivalent probe for AI-2 quorum-sensing receptors.

Amanda L Garner, Junguk Park, Joseph S Zakhari, Colin A Lowery, Anjali Kumari Struss, Daisuke Sawada, Gunnar F Kaufmann, Kim D Janda

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.4field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 24 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Amanda L GarnerDepartment of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
Junguk Park
Joseph S Zakhari
Colin A Lowery
Anjali Kumari Struss
Daisuke Sawada
Gunnar F Kaufmann
Kim D Janda
Scripps Research Institute · US

Funding

Chemical Strategies to Manipulate A1-2 Signaling in Bacterial PathogensR01AI077644 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI JANDA, KIM · 2010 to 2014
$2.3M
Bacterial Quorum Sensing as Target for Anti-Infective ImmunotherapyR01AI080715 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI ZHOU, BIN · 2009 to 2013
$2.3M
Bacterial acyl homoserine lactones as immune modulators and drug targetsR21AI085324 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI KAUFMANN, GUNNAR JOERG FLORIS · 2010 to 2011
$519k
NIAID NIH HHS AI077644NIAID NIH HHS AI080715NIAID NIH HHS AI085324NIAID NIH HHS R01 AI077644NIAID NIH HHS R01 AI080715NIAID NIH HHS R21 AI085324
6 · The paper itself

Abstract

Multivalency is a common principle in the recognition of cellular receptors, and multivalent agonists and antagonists have played a major role in understanding mammalian cell receptor biology. The study of bacterial cell receptors using similar approaches, however, has lagged behind. Herein we describe our efforts toward the development of a dendrimer-based multivalent probe for studying AI-2 quorum-sensing receptors. From these studies, we have discovered a chemical probe specific for Lsr-type AI-2 quorum-sensing receptors with the potential for enabling the identification of new bacterial species that utilize AI-2 as a quorum-sensing signaling molecule.

Indexed as

Quorum SensingBacillus cereusBacteriaDendrimersFluorescent DyesMicroscopy, FluorescenceModels, MolecularPentanesRhodaminesSalmonella typhimuriumVibrio4,5-dihydroxy-2,3-pentanedioneDendrimersFluorescent DyesPentanesRhodamines

Identifiers

PMID21913711
PMCPMC3203215
OpenAlexW2023187720

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.