ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2011
From transporter to transceptor: signaling from transporters provokes re-evaluation of complex trafficking and regulatory controls: endocytic internalization and intracellular trafficking of nutrient transceptors may, at least in part, be governed by their signaling function.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed.
- Zinc-induced exposure of an LxL motif drives clathrin-mediated endocytosis of the zinc transceptor ZIP4.The Journal of biological chemistry · 2026Article
- Cystinosin/Ers1 functions in redox homeostasis in the early secretory pathway.bioRxiv : the preprint server for biology · 2026Article
- Arabidopsis HAK5 under low KNature communications · 2024Article
- Ammonia transporter RhBG initiates downstream signaling and functional responses by activating NFκB.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- How sensor Amt-like proteins integrate ammonium signals.Science advances · 2024Article
- Future opportunities in solute carrier structural biology.Nature structural & molecular biology · 2024Review
- Multiple roles for the cytoplasmic C-terminal domains of the yeast cell surface receptors Rgt2 and Snf3 in glucose sensing and signaling.Scientific reports · 2024Article
- Membrane transporters in cell physiology, cancer metabolism and drug response.Disease models & mechanisms · 2023Review
- General control nonderepressible 1 interacts with cationic amino acid transporter 1 and affects Aedes aegypti fecundity.Parasites & vectors · 2022Article
- SLC38A10 Regulate Glutamate Homeostasis and Modulate the AKT/TSC2/mTOR Pathway in Mouse Primary Cortex Cells.Frontiers in cell and developmental biology · 2022Article
- Nutrient transceptors physically interact with the yeast S6/protein kinase B homolog, Sch9, a TOR kinase target.The Biochemical journal · 2021Article
- Molecular basis for KDEL-mediated retrieval of escaped ER-resident proteins - SWEET talking the COPs.Journal of cell science · 2020Review
- Nitrate in 2020: Thirty Years from Transport to Signaling Networks.The Plant cell · 2020Review
- Regulation of Amino Acid Transport in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 2019Review
- Phosphate (PThe Journal of biological chemistry · 2018Article
- pH homeostasis in yeast; the phosphate perspective.Current genetics · 2018Review
- Multiple Transceptors for Macro- and Micro-Nutrients Control Diverse Cellular Properties Through the PKA Pathway in Yeast: A Paradigm for the Rapidly Expanding World of Eukaryotic Nutrient Transceptors Up to Those in Human Cells.Frontiers in pharmacology · 2018Review
- HJournal of bioenergetics and biomembranes · 2017Article
- Identification of Ftr1 and Zrt1 as iron and zinc micronutrient transceptors for activation of the PKA pathway inMicrobial cell (Graz, Austria) · 2017Article
- Transceptors as a functional link of transporters and receptors.Microbial cell (Graz, Austria) · 2017Article
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When cells are starved of their substrate, many nutrient transporters are induced. These undergo rapid endocytosis and redirection of their intracellular trafficking when their substrate becomes available again. The discovery that some of these transporters also act as receptors, or transceptors, suggests that at least part of the sophisticated controls governing the trafficking of these proteins has to do with their signaling function rather than with control of transport. In yeast, the general amino acid permease Gap1 mediates signaling to the protein kinase A pathway. Its endocytic internalization and intracellular trafficking are subject to amino acid control. Other nutrient transceptors controlling this signal transduction pathway appear to be subject to similar trafficking regulation. Transporters with complex regulatory control have also been suggested to function as transceptors in other organisms. Hence, precise regulation of intracellular trafficking in nutrient transporters may be related to the need for tight control of nutrient-induced signaling.
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