ArticleInternational journal of behavioral medicine2012
Racial discrimination is associated with a measure of red blood cell oxidative stress: a potential pathway for racial health disparities.
Article in International journal of behavioral medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 4 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
75 citing papers in PubMed, 4 syntheses or guidelines pooled it, 100 citations in OpenAlex.
- Racial/Ethnic Discrimination and Cardiometabolic Diseases: A Systematic Review.Journal of racial and ethnic health disparities · 2024Pooled it
- Self-reported experiences of discrimination and health: scientific advances, ongoing controversies, and emerging issues.Annual review of clinical psychology · 2015Pooled it
- Pooled it
- Depression and oxidative stress: results from a meta-analysis of observational studies.Psychosomatic medicine · 2014Pooled it
- Associations of weight stigma with cortisol and oxidative stress independent of adiposity.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2014Trial
- Association of mitochondrial DNA haplogroup, oxidative DNA damage and inflammatory markers in middle-aged adults.International journal of radiation biology · 2026Article
- Combined effects of heavy metals and volatile organic compounds on oxidative stress and cardiovascular risk.American heart journal plus : cardiology research and practice · 2026Article
- Associations of Racial Discrimination with Resting-state Network Topology: A Mechanism for Post-traumatic Sensory Disruptions.Research square · 2026Article
- The relationship between racial discrimination and white matter among Black older adults.Neurobiology of aging · 2025Article
- Age and gender intersectionality among African Americans: Salivary uric acid is associated with shorter telomere length in younger adults and men.Psychoneuroendocrinology · 2025Article
- The interface of geroscience with longitudinal health disparities research: a 20-year retrospective of the Healthy Aging in Neighborhoods of Diversity across the Life Span study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Examining the Health Risk Pathways Between Discrimination and Accelerated Biological Aging Among a Population-Based Sample of Older Adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Multilevel Racism and Discrimination and Cardiovascular Disease and Related Biopsychosocial Mechanisms: An Integrated Scoping and Literature Review and Future Research Agenda.Current cardiology reports · 2025Article
- Associations of perceived discrimination with health outcomes and health disparities in the All of Us cohort.Journal of the American Medical Informatics Association : JAMIA · 2025Article
- Persistent Effect of Redlining on Survival from Screenable Cancers in Washington State, 2000-2018.Journal of urban health : bulletin of the New York Academy of Medicine · 2025Article
- Article
- Oxidative Stress Early After Hematopoietic Stem Cell Transplant.Transplantation and cellular therapy · 2025Article
- Lifetime Stressor Severity and Diurnal Cortisol in Older African American Adults: A Comparison of Three Theoretical Models.Developmental psychobiology · 2025Article
- Genome-wide transcriptome differences associated with perceived discrimination in an urban, community-dwelling middle-aged cohort.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Getting to the Heart of the Matter: Exploring the Intersection of Cardiovascular Disease, Sex and Race and How Exercise, and Gut Microbiota Influence these Relationships.Reviews in cardiovascular medicine · 2025Review
15 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundThere are racial health disparities in many conditions for which oxidative stress is hypothesized to be a precursor. These include cardiovascular disease, diabetes, and premature aging. Small clinical studies suggest that psychological stress may increase oxidative stress. However, confirmation of this association in epidemiological studies has been limited by homogenous populations and unmeasured potential confounders. PURPOSE: We tested the cross-sectional association between self-reported racial discrimination and red blood cell (RBC) oxidative stress in a biracial, socioeconomically heterogeneous population with well-measured confounders.
methodsWe performed a cross-sectional analysis of a consecutive series of 629 participants enrolled in the Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. Conducted by the National Institute on Aging Intramural Research Program, HANDLS is a prospective epidemiological study of a socioeconomically diverse cohort of 3,721 Whites and African Americans aged 30-64 years. Racial discrimination was based on self-report. RBC oxidative stress was measured by fluorescent heme degradation products. Potential confounders were age, smoking status, obesity, and C-reactive protein.
resultsParticipants had a mean age of 49 years (SD = 9.27). In multivariable linear regression models, racial discrimination was significantly associated with RBC oxidative stress (Beta = 0.55, P < 0.05) after adjustment for age, smoking, C-reactive protein level, and obesity. When stratified by race, discrimination was not associated with RBC oxidative stress in Whites but was associated significantly for African Americans (Beta = 0.36, P < 0.05).
conclusionsThese findings suggest that there may be identifiable cellular pathways by which racial discrimination amplifies cardiovascular and other age-related disease risks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.