ArticleAnnals of surgical oncology2012
Clinicopathologic features of incident and subsequent tumors in patients with multiple primary cutaneous melanomas.
Article in Annals of surgical oncology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Melanoma patients under vemurafenib: prospective follow-up of melanocytic lesions by digital dermoscopy.The Journal of investigative dermatology · 2014Trial
- Article
- Association of multiple primary melanomas with malignancy risk: A population-based analysis of entries from the Surveillance, Epidemiology, and End Results program database during 1973-2014.Journal of the American Academy of Dermatology · 2023Article
- Disease-Associated Risk Variants inCancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Article
- Multiple Thick Nodular Melanoma: Differentiating Multiple Primaries from the Metastasis of a Previous Single MelanomaBalkan medical journal · 2019Article
- Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes.The Journal of investigative dermatology · 2018Article
- Metastases risk in thin cutaneous melanoma: prognostic value of clinical-pathologic characteristics and mutation profile.Oncotarget · 2018Article
- Similar survival of patients with multiple versus single primary melanomas based on Utah Surveillance, Epidemiology, and End Results data (1973-2011).Journal of the American Academy of Dermatology · 2018Article
- Second Primary Melanoma: Risk Factors, Histopathologic Features, Survival, and Implications for Follow-Up.The American surgeon · 2016Article
- Eleven Primary Melanomas, Colon Cancer, and Atypical Nevi in the Same Patient: A Case Report and Literature Review.Case reports in dermatological medicine · 2016Article
- Association Between NRAS and BRAF Mutational Status and Melanoma-Specific Survival Among Patients With Higher-Risk Primary Melanoma.JAMA oncology · 2015Article
- Epidemiological and genetic factors underlying melanoma development in Italy.Melanoma management · 2015Review
- Comparison of clinicopathologic features and survival of histopathologically amelanotic and pigmented melanomas: a population-based study.JAMA dermatology · 2014Article
- Discrepant alterations in main candidate genes among multiple primary melanomas.Journal of translational medicine · 2014Article
- Phenotypic characterization of nevus and tumor patterns in MITF E318K mutation carrier melanoma patients.The Journal of investigative dermatology · 2014Article
- Melanoma risk loci as determinants of melanoma recurrence and survival.Journal of translational medicine · 2013Article
- Distribution of MC1R variants among melanoma subtypes: p.R163Q is associated with lentigo maligna melanoma in a Mediterranean population.The British journal of dermatology · 2013Observational
- Survival for patients with single and multiple primary melanomas: the genes, environment, and melanoma study.JAMA dermatology · 2013Article
Corrections and comments
- Erratum issued
Authors and funding
16 authors at 5 institutions in 3 countries.
Funding
Abstract
background0.6-12.7% of patients with primary cutaneous melanoma will develop additional melanomas. Pathologic features of tumors in patients with multiple primary cutaneous melanomas have not been well described. In this large, international, multicenter, case-control study, we compared the clinicopathologic features of a subsequent melanoma with the preceding (usually the first) melanoma in patients with multiple primary cutaneous melanomas, and with those of melanomas in patients with single primary cutaneous melanomas.
methodsMultiple primary melanoma (cases) and single primary invasive melanoma (controls) patients from the Genes, Environment and Melanoma (GEM) study were included if their tumors were available for pathologic review and confirmed as melanoma. Clinicopathologic characteristics of invasive subsequent and first melanomas in cases and invasive single melanomas in controls were compared.
resultsA total of 473 pairs comprising a subsequent and a first melanoma and 1,989 single melanomas were reviewed. Forward stepwise regression modeling in 395 pairs with complete data showed that, compared with first melanomas, subsequent melanomas were more commonly contiguous with a dysplastic nevus, more prevalent on the head/neck and legs than other sites, and thinner. Compared with single primary melanomas, subsequent melanomas were more likely to be associated with a contiguous dysplastic nevus, more prevalent on the head/neck and legs, and thinner. The same differences were observed when subsequent melanomas were compared with single melanomas. First melanomas were more likely than single melanomas to have associated solar elastosis and no observed mitoses.
conclusionsThinner subsequent than first melanomas suggest earlier diagnosis, perhaps due to closer clinical scrutiny. The association of subsequent melanomas with dysplastic nevi is consistent with the latter being risk factors or risk markers for melanoma.
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