ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2011
Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
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- Renal histaminergic system and acute effects of histamine receptor 2 blockade on renal damage in the Dahl salt-sensitive rat.American journal of physiology. Renal physiology · 2023Article
- Gut Barrier Dysfunction and Type 2 Immunity: Implications for Compulsive Behavior.Medical hypotheses · 2022Article
- The implications of histamine metabolism and signaling in renal function.Physiological reports · 2021Review
- Histamine can be Formed and Degraded in the Human and Mouse Heart.Frontiers in pharmacology · 2021Article
- Histamine pharmacology: from Sir Henry Dale to the 21st century.British journal of pharmacology · 2020Review
- Histamine in the kidneys: what is its role in renal pathophysiology?British journal of pharmacology · 2020Review
- Serum histamine and acetylcholine variations as new noninvasive biochemical markers in staging of experimental hepatocellular carcinoma.Clinical and experimental medicine · 2019Article
- Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutants in the Sf9 Cell Expression System.Handbook of experimental pharmacology · 2017Review
- International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors.Pharmacological reviews · 2015Review
- Histamine H₄ receptors in the gastrointestinal tract.British journal of pharmacology · 2015Review
- Roles of basophils and mast cells infiltrating the lung by multiple antigen challenges in asthmatic responses of mice.British journal of pharmacology · 2013Article
- Histamine and histamine receptor regulation of gastrointestinal cancers.Translational gastrointestinal cancer · 2012Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
objectiveHistamine plays a role in several (patho) physiological processes that are commonly studied in mouse models. However, a systematic quantification of histamine and its metabolite N-methylhistamine in mouse organs has not been reported so far.
methodsBalb/c and C57Bl/6 mice were grouped according to their sex and age. Brains, hearts, lungs, livers, kidneys, stomachs, intestines, thymi, spleens, and lymph nodes were excised, weighed, and homogenized. Histamine and N-methylhistamine were quantified simultaneously by a HPLC-mass spectrometry method.
resultsIn all organs analyzed, histamine and N-methylhistamine were detected; however, with quantitative differences. Histamine was present most abundantly in the stomach, lymph nodes, and thymus. The lowest histamine concentrations were detected in brain, liver, lung, and intestine. In most organs, the histamine concentrations increased age-dependently. Substantial concentrations of N-methylhistamine were detected only in lung, intestine and kidney, while in all other organs it was present only in minor quantities.
conclusionHPLC-mass spectrometry is a useful method for the highly sensitive and simultaneous detection of histamine and N-methylhistamine. Histamine is present in virtually all organs, not only in those traditionally associated with histamine-mediated disease. Highest concentrations are found in stomach, lymph node, and thymus; medium concentrations in heart, spleen, and kidney; and lowest concentrations detected in intestine, brain, liver, and lung.
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