ArticleParasitology research2012
The sensitivity of artesunate against Schistosoma japonicum decreased after 10 years of use in China?
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis.Parasites & vectors · 2011Pooled it
- New clinical application prospects of artemisinin and its derivatives: a scoping review.Infectious diseases of poverty · 2023Article
- New uses for old drugs: the tale of artemisinin derivatives in the elimination of schistosomiasis japonica in China.Molecules (Basel, Switzerland) · 2014Review
- A review of dihydroartemisinin as another gift from traditional Chinese medicine not only for malaria control but also for schistosomiasis control.Parasitology research · 2014Review
- Stem cell therapy for the treatment of parasitic infections: is it far away?Parasitology research · 2014Article
- Dihydroartemisinin: a new story of an old drug against Schistosoma mansoni infection.Parasitology research · 2014Article
- Artemisinin: the gifts from traditional Chinese medicine not only for malaria control but also for schistosomiasis control.Parasitology research · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Artesuante (AS) is a good chemoprophylactic drug for preventing against schistosome infection, but Hua et al. recently reported that the sensitivity of AS against Schistosoma japonicum decreased after 10 years of use in China. There are at least three problems, to our knowledge, making the finding suspicious or inconclusive in that report. In consideration of it as the first report about the emergence of potential artemisinin derivative-resistant S. japonicum to date and the possible severe influences of the emergence of AS-resistant S. japonicum on the future choice of chemoprophylactic drugs for preventing against S. japonicum infections in China, we write this comment and call for some more rigorous and convincing trials to confirm this finding further.
Indexed as
Identifiers
21912960What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.