ArticleEuropean journal of pediatrics2012
European survey on the use of prophylactic fluconazole in neonatal intensive care units.
Article in European journal of pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Prophylactic oral/topical non-absorbed antifungal agents to prevent invasive fungal infection in very low birth weight infants.The Cochrane database of systematic reviews · 2015Pooled it
- Prophylactic systemic antifungal agents to prevent mortality and morbidity in very low birth weight infants.The Cochrane database of systematic reviews · 2015Pooled it
- Pharmacokinetics and safety of fluconazole and micafungin in neonates with systemic candidiasis: a randomized, open-label clinical trial.British journal of clinical pharmacology · 2018Trial
- Irrational and Inappropriate Use of Antifungals in the NICU: A Narrative Review.Antibiotics (Basel, Switzerland) · 2026Review
- Article
- Variations in Antibiotic Use and Sepsis Management in Neonatal Intensive Care Units: A European Survey.Antibiotics (Basel, Switzerland) · 2021Article
- Prophylactic Use of Fluconazole in Very Premature Infants.Frontiers in pediatrics · 2021Article
- Synthesis, Optimization, Antifungal Activity, Selectivity, and CYP51 Binding of New 2-Aryl-3-azolyl-1-indolyl-propan-2-ols.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Performance of a Quantitative PCR-Based Assay and Beta-d-Glucan Detection for Diagnosis of Invasive Candidiasis in Very-Low-Birth-Weight Preterm Neonatal Patients (CANDINEO Study).Journal of clinical microbiology · 2017Observational
- Pattern of drug use among preterm neonates: results from an Italian neonatal intensive care unit.Italian journal of pediatrics · 2017Article
- Drug versus placebo randomized controlled trials in neonates: A review of ClinicalTrials.gov registry.PloS one · 2017Article
- Pulse oximeter saturation target limits for preterm infants: a survey among European neonatal intensive care units.European journal of pediatrics · 2017Article
- Off-label and unlicensed drug treatments in Neonatal Intensive Care Units: an Italian multicentre study.European journal of clinical pharmacology · 2016Article
- High variability in the dosing of commonly used antibiotics revealed by a Europe-wide point prevalence study: implications for research and dissemination.BMC pediatrics · 2015Article
- Ureaplasma, bronchopulmonary dysplasia, and azithromycin in European neonatal intensive care units: a survey.Scientific reports · 2014Article
- Wide intra- and inter-country variability in drug use and dosage in very-low-birth-weight newborns with severe infections.European journal of clinical pharmacology · 2013Article
- The use of ciprofloxacin and fluconazole in Italian neonatal intensive care units: a nationwide survey.BMC pediatrics · 2013Article
- Prescription of off-label and unlicensed drugs for preterm infants in a neonatal intensive care unit.Revista Brasileira de terapia intensivaArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledNeonatal fungal infections are associated with substantial mortality and morbidity. Although prophylactic use of several antifungals has been proposed, this practice remains controversial. In order to evaluate the use of fluconazole prophylaxis in European NICUs, we conducted a cross-sectional survey by means of a structured questionnaire that was sent to European level II and III neonatal intensive care units, over a 9-month period, as part of a neonatal research FP7 European project. A total of 193 questionnaires from 28 countries were analysed. Use of antifungal prophylaxis was reported by 55% of the responders, and the most frequently used antifungal agent was fluconazole (92%). Main indications for prophylaxis were low gestational age (<28 weeks) and birth weight (<1,000 g). A dose of 3 mg/kg was used in 66% of NICUs using fluconazole, with an administration interval of 72 h in 52% of them. All responders acknowledged the need for additional trials on the efficacy of prophylactic fluconazole. Non-users of fluconazole prophylaxis were more likely to be influenced by the local incidence of candidiasis, the risk of increasing antifungal resistance and the absence of specific recommendations by paediatric societies.
conclusionsMajor concerns about the use of fluconazole prophylaxis include its efficacy, the risk of emergence of resistant species and the absence of clear consensus to support routine use. Future studies that address these issues will contribute to a more rational use of fluconazole prophylaxis.
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