ArticleParasitology research1990
IgG response of rats to the excretory-secretory products of Litomosoides carinii.
Article in Parasitology research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 5 citations in OpenAlex.
- A comprehensive, model-based review of vaccine and repeat infection trials for filariasis.Clinical microbiology reviews · 2013Review
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nature of antibody responses to the excretory-secretory (ES) products of adult worms and microfilariae (Mf) of Litomosoides carinii in albino rats and their possible role in protection have been studied. Rats were immunized with ES products derived from in vitro incubation of adults or Mf. The sera from these rats promoted neutrophil-mediated killing of Mf in vitro. The antibody responsible for the cytocidal activity was identified as IgG isotype. Indirect fluorescent antibody test showed the presence of IgG on the surface of Mf incubated in either of the immune sera. The immune sera were effective in clearing the circulating Mf in Mastomys natalensis, indicating the protective nature of the antibody. Thus, L. carinii in culture liberate functional antigens that seem to have protective potential.
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