ArticleStroke research and treatment2011
Genetics of common polygenic ischaemic stroke: current understanding and future challenges.
Article in Stroke research and treatment, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Genetic Overlap Between Obstructive Sleep Apnea and Ischemic Stroke: A Large-Scale Genome-Wide Cross-Trait Analysis.Nature and science of sleep · 2025Article
- Identification and prediction of molecular factors associated with ischemic stroke: an integrative analysis of DEGs, TFs, and PPI networks.In vitro models · 2023Article
- Monogenic basis of young-onset cryptogenic stroke: a multicenter study.Annals of translational medicine · 2022Article
- Pathophysiology of Lacunar Stroke: History's Mysteries and Modern Interpretations.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019Review
- Genetic Variants of RAMP2 and CLR are Associated with Stroke.Journal of atherosclerosis and thrombosis · 2017Article
- Relationship between Interleukin-6 (-174G/C and -572C/G) Promoter Gene Polymorphisms and Risk of Intracerebral Hemorrhage: A Meta-Analysis.Pulse (Basel, Switzerland) · 2016Review
- Genetic association between inflammatory genes (IL-1α, CD14, LGALS2, PSMA6) and risk of ischemic stroke: A meta-analysis.Meta gene · 2016Review
- Association between Tumor Necrosis Factor-α (-238G/A and -308G/A) Gene Polymorphisms and Risk of Ischemic Stroke: A Meta-Analysis.Pulse (Basel, Switzerland) · 2016Review
- Interleukin-6 Receptor Polymorphisms Contribute to the Neurological Status of Korean Patients with Ischemic Stroke.Journal of Korean medical science · 2016Article
- Article
- Association ofExperimental and therapeutic medicine · 2016Article
- Genetic risk factors for spontaneous intracerebral haemorrhage.Nature reviews. Neurology · 2016Review
- Association of GWAS-Supported Variants rs2200733 and rs6843082 on Chromosome 4q25 with Ischemic Stroke in the Southern Chinese Han Population.Journal of molecular neuroscience : MN · 2015Article
- Genetics of ischaemic stroke in young adults.BBA clinical · 2015Review
- The NLRP3 inflammasome and stroke.International journal of clinical and experimental medicine · 2015Review
- The architecture of risk for type 2 diabetes: understanding Asia in the context of global findings.International journal of endocrinology · 2014Review
- Commentary on a GWAS: HDAC9 and the risk for ischaemic stroke.BMC medicine · 2012Article
- Stroke genomics in people of African ancestry: charting new paths.Cardiovascular journal of AfricaReview
- Lombardia GENS: a collaborative registry for monogenic diseases associated with stroke.Functional neurologyArticle
- Effects ofClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisObservational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is the third commonest cause of death and the major cause of adult neurological disability worldwide. While much is known about conventional risk factors such as hypertension, diabetes and incidence of smoking, these environmental factors only account for a proportion of stroke risk. Up to 50% of stroke risk can be attributed to genetic risk factors, although to date no single risk allele has been convincingly identified as contributing to this risk. Advances in the field of genetics, most notably genome wide association studies (GWAS), have revealed genetic risks in other cardiovascular disease and these techniques are now being applied to ischaemic stroke. This paper covers previous genetic studies in stroke including candidate gene studies, discusses the genome wide association approach, and future techniques such as next generation sequencing and the post-GWAS era. The review also considers the overlap from other cardiovascular diseases and whether findings from these may also be informative in ischaemic stroke.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.