ReviewNeural plasticity2011
Interplay of amygdala and cingulate plasticity in emotional fear.
Review in Neural plasticity, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Dynamic representations of valence in anterior cingulate cortex in mice.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Increased c-Fos expression in lateral habenula during social transmission of negative valence in prairie voles.Molecular autism · 2026Article
- Perinatal compromise affects development, form, and function of the hippocampus part one; clinical studies.Pediatric research · 2024Review
- Activation of the glutamatergic cingulate cortical-cortical connection facilitates pain in adult mice.Communications biology · 2023Article
- Neural correlates of social exclusion and overinclusion in patients with borderline personality disorder: an fMRI study.Borderline personality disorder and emotion dysregulation · 2023Article
- Changes in brain rhythms and connectivity tracking fear acquisition and reversal.Brain structure & function · 2023Article
- The impact of studying on the hippocampal volume in medical students and its correlation with the results of the Final Medical Examination: a single-centre, prospective observational cohort study.Polish journal of radiology · 2023Article
- Oral Contraceptives Modulate the Relationship Between Resting Brain Activity, Amygdala Connectivity and Emotion Recognition - A Resting State fMRI Study.Frontiers in behavioral neuroscience · 2022Article
- The Mind After Midnight: Nocturnal Wakefulness, Behavioral Dysregulation, and Psychopathology.Frontiers in network physiology · 2022Article
- Internalizing-externalizing comorbidity and regional brain volumes in the ABCD study.Development and psychopathology · 2021Article
- Early Development of the GABAergic System and the Associated Risks of Neonatal Anesthesia.International journal of molecular sciences · 2021Review
- Neurogenesis in the adult brain functionally contributes to the maintenance of chronic neuropathic pain.Scientific reports · 2021Article
- Resting-State Directional Connectivity and Anxiety and Depression Symptoms in Adult Cannabis Users.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2021Article
- Distribution and overlap of entorhinal, premotor, and amygdalar connections in the monkey anterior cingulate cortex.The Journal of comparative neurology · 2021Article
- Optogenetic Manipulations of Amygdala Neurons Modulate Spinal Nociceptive Processing and Behavior Under Normal Conditions and in an Arthritis Pain Model.Frontiers in pharmacology · 2021Article
- Kappa opioid receptors in the central amygdala modulate spinal nociceptive processing through an action on amygdala CRF neurons.Molecular brain · 2020Article
- The Suppression of Taboo Word Spoonerisms Is Associated With Altered Medial Frontal Negativity: An ERP Study.Frontiers in human neuroscience · 2020Article
- Optogenetic reactivation of memory ensembles in the retrosplenial cortex induces systems consolidation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Impact of sex and reproductive status on memory circuitry structure and function in early midlife using structural covariance analysis.Human brain mapping · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
The amygdala is known to be a critical brain region for emotional fear. It is believed that synaptic plasticity within the amygdala is the cellular basis of fear memory. Recent studies demonstrate that cortical areas such as the prefrontal cortex (PFC) and anterior cingulate cortex (ACC) may also contribute to the formation of fear memory, including trace fear memory and remote fear memory. At synaptic level, fear conditioning also triggers plastic changes within the cortical areas immediately after the condition. These results raise the possibility that certain forms of synaptic plasticity may occur within the cortex while synaptic potentiation takes place within synapses in the hippocampus and amygdala. This hypothesis is supported by electrophysiological evidence obtained from freely moving animals that neurons in the hippocampus/amygdala fire synchronous activities with cortical neurons during the learning. To study fear-related synaptic plasticity in the cortex and its functional connectivity with neurons in the amygdala and hippocampus will help us understand brain mechanisms of fear and improve clinical treatment of emotional disorders in patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.