ReviewPLoS neglected tropical diseases2011
Chronic hepatosplenomegaly in African school children: a common but neglected morbidity associated with schistosomiasis and malaria.
Review in PLoS neglected tropical diseases, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 63 citations in OpenAlex.
- Hemophagocytic Lymphohistiocytosis Criteria Overlap with Severe Malaria Features in Children.Open forum infectious diseases · 2026Article
- Prediction of 6-year mortality in advanced splenomegaly-subtype schistosomiasis: a retrospective cohort study from Hubei, China.BMJ open · 2026Article
- Liver and bladder morbidity in a Schistosoma mansoni and haematobium co-endemic area in the Democratic Republic of Congo.PLoS neglected tropical diseases · 2026Article
- The Basel ultrasonography protocol for assessing hepatosplenic pathologies in Asian schistosomiasis: report of a WHO expert meeting.Infectious diseases of poverty · 2025Article
- Biochemical, coagulation, and platelet count profiles among Schistosoma mansoni infected patients attending at selected Dembiya health institutions, Northwest Ethiopia.BMC microbiology · 2025Article
- IRF4 regulates myeloid-derived suppressor cells expansion and function in Schistosoma japonicum-infected mice.Parasites & vectors · 2024Article
- Effects of nanocapsules containing lumefantrine and artemether in an experimental model of cerebral malaria.Discover nano · 2024Article
- Effect of Malaria andJournal of tropical medicine · 2024Article
- Cloning, characterization, and inhibition of the novel β-carbonic anhydrase from parasitic blood fluke,Journal of enzyme inhibition and medicinal chemistry · 2023Article
- Protein undernutrition reduces the efficacy of praziquantel in a murine model of Schistosoma mansoni infection.PLoS neglected tropical diseases · 2022Article
- Sociality predicts individual variation in the immunity of free-ranging rhesus macaques.Physiology & behavior · 2021Article
- Diagnosis and clinical management of hepatosplenic schistosomiasis: A scoping review of the literature.PLoS neglected tropical diseases · 2021Article
- Is there a role for bedside ultrasound in malaria? A survey of the literature.Journal of ultrasound · 2020Review
- Hepatocyte-derived IL-10 plays a crucial role in attenuating pathogenicity during the chronic phase of T. congolense infection.PLoS pathogens · 2020Article
- Schistosomiasis Pulmonary Arterial Hypertension.Frontiers in immunology · 2020Review
- Efficacy ofJournal of traditional and complementary medicine · 2019Article
- Probiotics and yogurt modulate oxidative stress and fibrosis in livers of Schistosoma mansoni-infected mice.BMC complementary and alternative medicine · 2019Article
- Protozoan ParasiteFrontiers in microbiology · 2019Article
- Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d'Ivoire.PLoS neglected tropical diseases · 2019Article
- Schistosomiasis in School Age Children in Sierra Leone After 6 Years of Mass Drug Administration With Praziquantel.Frontiers in public health · 2019Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Chronic hepatosplenomegaly, which is known to have a complex aetiology, is common amongst children who reside in rural areas of sub-Saharan Africa. Two of the more common infectious agents of hepatosplenomegaly amongst these children are malarial infections and schistosomiasis. The historical view of hepatosplenomegaly associated with schistosomiasis is that it is caused by gross periportal fibrosis and resulting portal hypertension. The introduction of ultrasound examinations into epidemiology studies, used in tandem with clinical examination, showed a dissociation within endemic communities between presentation with hepatosplenomegaly and ultrasound periportal fibrosis, while immuno-epidemiological studies indicate that rather than the pro-fibrotic Th2 response that is associated with periportal fibrosis, childhood hepatosplenomegaly without ultrasound-detectable fibrosis is associated with a pro-inflammatory response. Correlative analysis has shown that the pro-inflammatory response is also associated with chronic exposure to malarial infections and there is evidence of exacerbation of hepatosplenomegaly when co-exposure to malaria and schistosomiasis occurs. The common presentation with childhood hepatosplenomegaly in rural communities means that it is an important example of a multi-factorial disease and its association with severe and subtle morbidities underlies the need for well-designed public health strategies for tackling common infectious diseases in tandem rather than in isolation.
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