Evidence map›Paper›PMID 21912659›Full record

Trial reportPloS one2011

Gene expression and biological pathways in tissue of men with prostate cancer in a randomized clinical trial of lycopene and fish oil supplementation.

Mark Jesus M Magbanua, Ritu Roy, Eduardo V Sosa, Vivian Weinberg, Scott Federman, Michael D Mattie, Millie Hughes-Fulford, Jeff Simko, Katsuto Shinohara, Christopher M Haqq and 2 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00402285 (The Molecular Effects of Nutrition Supplements), which is not on this map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00402285 nacompletednot on this map

The Molecular Effects of Nutrition Supplements (MENS) Prostate Study

TypeinterventionalSponsorUniversity of California, San FranciscoRan2003 to 2008Enrolled84ConditionsProstate CancerArmslycopene supplement, fish oil supplement, Placebo
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 61 citations in OpenAlex.

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  6. Carotenoids in Health as Studied by Omics-Related Endpoints.Advances in nutrition (Bethesda, Md.) · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Mark Jesus M MagbanuaHelen Diller Family Comprehensive Cancer Center, University of California San Francisco, San Francisco, California, United States of America.
Ritu Roy
Eduardo V Sosa
Vivian Weinberg
Scott Federman
Michael D Mattie
Millie Hughes-Fulford
Jeff Simko
Katsuto Shinohara
Christopher M Haqq
Peter R Carroll
June M Chan
University of California, San Francisco · USUCSF Helen Diller Family Comprehensive Cancer Center · US

Funding

Molecular Effects of Nutrition Supplements in ProstateR01CA101042 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CARROLL, PETER R · 2003 to 2007
$1.7M
NCI NIH HHS R01 CA101042NCI NIH HHS R01 R01CA101042
6 · The paper itself

Abstract

backgroundStudies suggest that micronutrients may modify the risk or delay progression of prostate cancer; however, the molecular mechanisms involved are poorly understood. We examined the effects of lycopene and fish oil on prostate gene expression in a double-blind placebo-controlled randomized clinical trial.

methodsEighty-four men with low risk prostate cancer were stratified based on self-reported dietary consumption of fish and tomatoes and then randomly assigned to a 3-month intervention of lycopene (n = 29) or fish oil (n = 27) supplementation or placebo (n = 28). Gene expression in morphologically normal prostate tissue was studied at baseline and at 3 months via cDNA microarray analysis. Differential gene expression and pathway analyses were performed to identify genes and pathways modulated by these micronutrients.

resultsGlobal gene expression analysis revealed no significant individual genes that were associated with high intake of fish or tomato at baseline or after 3 months of supplementation with lycopene or fish oil. However, exploratory pathway analyses of rank-ordered genes (based on p-values not corrected for multiple comparisons) revealed the modulation of androgen and estrogen metabolism in men who routinely consumed more fish (p = 0.029) and tomato (p = 0.008) compared to men who ate less. In addition, modulation of arachidonic acid metabolism (p = 0.01) was observed after 3 months of fish oil supplementation compared with the placebo group; and modulation of nuclear factor (erythroid derived-2) factor 2 or Nrf2-mediated oxidative stress response for either supplement versus placebo (fish oil: p = 0.01, lycopene: p = 0.001).

conclusionsWe did not detect significant individual genes associated with dietary intake and supplementation of lycopene and fish oil. However, exploratory analyses revealed candidate in vivo pathways that may be modulated by these micronutrients.

trial registrationClinicalTrials.gov NCT00402285.

Indexed as

Dietary SupplementsGene Expression ProfilingCarotenoidsDietDouble-Blind MethodFish OilsGene Expression Regulation, NeoplasticHumansLycopeneMaleOligonucleotide Array Sequence AnalysisPlacebosProstatic NeoplasmsCarotenoidsFish OilsLycopenePlacebos

Identifiers

PMID21912659
PMCPMC3164676
OpenAlexW2134349613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.