ArticlePloS one2011
Topological and functional characterization of an insect gustatory receptor.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 76 papers.
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76 citing papers in PubMed.
- Antennal transcriptome analysis and expression profiling of odorant binding proteins and odorant receptors in the teak defoliator, Hyblaea puera (Lepidoptera: Hyblaeidae).BMC genomics · 2026Article
- The lepidopteran analyst: how caterpillars, moths and butterflies encode taste identity and valence.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026Review
- Expanding the sensory horizon: chemosensory receptors beyond traditional olfactory and taste organs in insects.Science China. Life sciences · 2026Review
- Insect Sterols and Steroids.Advances in experimental medicine and biology · 2026Review
- The sensory arsenal mosquitoes use to find us.Trends in parasitology · 2025Review
- HarmGR13 mediates myo-inositol taste perception in Helicoverpa armigera larvae.PLoS genetics · 2025Article
- Life-stage dependent behavior mimics chemosensory repertoire diversity in a belowground, specialist herbivore.G3 (Bethesda, Md.) · 2025Article
- A structural perspective on insect gustatory receptors.Chemical senses · 2025Review
- Harnessing Insect Chemosensory and Mechanosensory Receptors Involved in Feeding for Precision Pest Management.Life (Basel, Switzerland) · 2025Review
- Evolutionary Genomics of Gene Families: A Case Study of Insect Gustatory Receptors.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Molecular Functions and Physiological Roles of Gustatory Receptors of the SilkwormInternational journal of molecular sciences · 2024Review
- The Neurotranscriptome ofInternational journal of molecular sciences · 2024Article
- Molecular sensors in the taste system of Drosophila.Genes & genomics · 2023Review
- Article
- Transcriptome analysis and identification of chemosensory genes in the larvae of Plagiodera versicolora.BMC genomics · 2022Article
- The chemosensory system of theFly · 2022Review
- The silkworm gustatory receptor BmGr63 is dedicated to the detection of isoquercetin in mulberry.Proceedings. Biological sciences · 2022Article
- Article
- Article
- Antennal transcriptome analysis of olfactory genes and tissue expression profiling of odorant binding proteins in Semanotus bifasciatus (cerambycidae: coleoptera).BMC genomics · 2022Article
16 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insect gustatory receptors are predicted to have a seven-transmembrane structure and are distantly related to insect olfactory receptors, which have an inverted topology compared with G-protein coupled receptors, including mammalian olfactory receptors. In contrast, the topology of insect gustatory receptors remains unknown. Except for a few examples from Drosophila, the specificity of individual insect gustatory receptors is also unknown. In this study, the total number of identified gustatory receptors in Bombyx mori was expanded from 65 to 69. BmGr8, a silkmoth gustatory receptor from the sugar receptor subfamily, was expressed in insect cells. Membrane topology studies on BmGr8 indicate that, like insect olfactory receptors, it has an inverted topology relative to G protein-coupled receptors. An orphan GR from the bitter receptor family, BmGr53, yielded similar results. We infer, from the finding that two distantly related BmGrs have an intracellular N-terminus and an odd number of transmembrane spans, that this is likely to be a general topology for all insect gustatory receptors. We also show that BmGr8 functions independently in Sf9 cells and responds in a concentration-dependent manner to the polyalcohols myo-inositol and epi-inositol but not to a range of mono- and di-saccharides. BmGr8 is the first chemoreceptor shown to respond specifically to inositol, an important or essential nutrient for some Lepidoptera. The selectivity of BmGr8 responses is consistent with the known responses of one of the gustatory receptor neurons in the lateral styloconic sensilla of B. mori, which responds to myo-inositol and epi-inositol but not to allo-inositol.
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