ArticleStem cells international2011
Embryonic stem cell-derived cardiomyocyte heterogeneity and the isolation of immature and committed cells for cardiac remodeling and regeneration.
Article in Stem cells international, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 28 citations in OpenAlex.
- Tissue Engineering Techniques for Induced Pluripotent Stem Cell Derived Three-Dimensional Cardiac Constructs.Tissue engineering. Part B, Reviews · 2022Review
- Exploring DNA Methylation Profiles Altered in Cryptogenic Hepatocellular Carcinomas by High-Throughput Targeted DNA Methylation Sequencing: A Preliminary Study for Cryptogenic Hepatocellular Carcinoma.OncoTargets and therapy · 2020Article
- The march of pluripotent stem cells in cardiovascular regenerative medicine.Stem cell research & therapy · 2018Review
- Investigation of human iPSC-derived cardiac myocyte functional maturation by single cell traction force microscopy.PloS one · 2018Article
- Cardiomyocytes in Young Infants With Congenital Heart Disease: a Three-Month Window of Proliferation.Scientific reports · 2016Article
- Cardiac Stem Cell Hybrids Enhance Myocardial Repair.Circulation research · 2015Article
- Emerging proteomic technologies for elucidating context-dependent cellular signaling events: A big challenge of tiny proportions.Proteomics · 2015Review
- Susceptibility of murine induced pluripotent stem cell-derived cardiomyocytes to hypoxia and nutrient deprivation.Stem cell research & therapy · 2015Article
- Hold or fold--proteins in advanced heart failure and myocardial recovery.Proteomics. Clinical applications · 2015Review
- Combining hypoxia and bioreactor hydrodynamics boosts induced pluripotent stem cell differentiation towards cardiomyocytes.Stem cell reviews and reports · 2014Article
- N-glycoprotein surfaceomes of four developmentally distinct mouse cell types.Proteomics. Clinical applications · 2014Article
- Mutations in Alström protein impair terminal differentiation of cardiomyocytes.Nature communications · 2014Article
- Article
- Strategies affording prevascularized cell-based constructs for myocardial tissue engineering.Stem cells international · 2014Review
- Mechanism-based facilitated maturation of human pluripotent stem cell-derived cardiomyocytes.Circulation. Arrhythmia and electrophysiology · 2013Article
- Differentiation of human ES cell line KIND-2 to yield tripotent cardiovascular progenitors.In vitro cellular & developmental biology. Animal · 2013Article
- Imaging Cell Therapy for Myocardial Regeneration.Current cardiovascular imaging reports · 2012Article
- Stem cells in heart failure.Stem cells international · 2011Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
Pluripotent stem cells represent one promising source for cell replacement therapy in heart, but differentiating embryonic stem cell-derived cardiomyocytes (ESC-CMs) are highly heterogeneous and show a variety of maturation states. In this study, we employed an ESC clonal line that contains a cardiac-restricted ncx1 promoter-driven puromycin resistance cassette together with a mass culture system to isolate ESC-CMs that display traits characteristic of very immature CMs. The cells display properties of proliferation, CM-restricted markers, reduced mitochondrial mass, and hypoxia-resistance. Following transplantation into rodent hearts, bioluminescence imaging revealed that immature cells, but not more mature CMs, survived for at least one month following injection. These data and comparisons with more mature cells lead us to conclude that immature hypoxia resistant ESC-CMs can be isolated in mass in vitro and, following injection into heart, form grafts that may mediate long-term recovery of global and regional myocardial contractile function following infarction.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.