ArticleExperimental diabetes research2011
Exercise increases insulin content and basal secretion in pancreatic islets in type 1 diabetic mice.
Article in Experimental diabetes research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Improvement and Retention of Insulin Secretion in Slowly Progressive Type 1 Diabetes Mellitus by Diet Therapy and Exercise for Five Years.Internal medicine (Tokyo, Japan) · 2025Article
- Microgravity Effect on Pancreatic Islets.Cells · 2024Article
- Role of diet and exercise in aging, Alzheimer's disease, and other chronic diseases.Ageing research reviews · 2023Review
- A perspective on treating type 1 diabetes mellitus before insulin is needed.Nature reviews. Endocrinology · 2023Review
- Exercise and inactivity as modifiers of β cell function and type 2 diabetes risk.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Review
- Pre-treatment with IL-6 potentiates β-cell death induced by pro-inflammatory cytokines.BMC molecular and cell biology · 2023Article
- The Effects of Exercise Training on Glucose Homeostasis and Muscle Metabolism in Type 1 Diabetic Female Mice.Metabolites · 2022Article
- Recombinant Reg3α Prevents Islet β-Cell Apoptosis and Promotes β-Cell Regeneration.International journal of molecular sciences · 2022Article
- Impacts of an Exercise Intervention on the Health of Pancreatic Beta-Cells: A Review.International journal of environmental research and public health · 2022Review
- PEGDA microencapsulated allogeneic islets reverse canine diabetes without immunosuppression.PloS one · 2022Article
- Physiological Changes and Pathological Pain Associated with Sedentary Lifestyle-Induced Body Systems Fat Accumulation and Their Modulation by Physical Exercise.International journal of environmental research and public health · 2021Review
- Effects of Different Intensity Exercise on Glucose Metabolism and Hepatic IRS/PI3K/AKT Pathway in SD Rats Exposed with TCDD.International journal of environmental research and public health · 2021Article
- The effects of exercise training versus intensive insulin treatment on skeletal muscle fibre content in type 1 diabetes mellitus rodents.Lipids in health and disease · 2021Article
- Resistance exercise training improves glucose homeostasis by enhancing insulin secretion in C57BL/6 mice.Scientific reports · 2021Article
- Response of Liver Metabolic Pathways to Ketogenic Diet and Exercise Are Not Additive.Medicine and science in sports and exercise · 2020Article
- Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels.Experimental neurology · 2018Article
- Elevated androgen levels induce hyperinsulinemia through increase in Ins1 transcription in pancreatic beta cells in female rats.Biology of reproduction · 2018Article
- Effects of leucine supplementation and resistance training on myopathy of diabetic rats.Physiological reports · 2017Article
- Article
- Prenatal Testosterone Exposure Leads to Gonadal Hormone-Dependent Hyperinsulinemia and Gonadal Hormone-Independent Glucose Intolerance in Adult Male Rat Offspring.Biology of reproduction · 2016Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Exercise appears to improve glycemic control for people with type 1 diabetes (T1D). However, the mechanism responsible for this improvement is unknown. We hypothesized that exercise has a direct effect on the insulin-producing islets. Eight-week-old mice were divided into four groups: sedentary diabetic, exercised diabetic, sedentary control, and exercised control. The exercised groups participated in voluntary wheel running for 6 weeks. When compared to the control groups, the islet density, islet diameter, and β-cell proportion per islet were significantly lower in both sedentary and exercised diabetic groups and these alterations were not improved with exercise. The total insulin content and insulin secretion were significantly lower in sedentary diabetics compared to controls. Exercise significantly improved insulin content and insulin secretion in islets in basal conditions. Thus, some improvements in exercise-induced glycemic control in T1D mice may be due to enhancement of insulin content and secretion in islets.
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