ArticlePLoS genetics2011
Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.
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Who cites it
100 citing papers in PubMed, 163 citations in OpenAlex.
- Elevated LncRNAFASEB bioAdvances · 2026Article
- Abnormal Sperm Morphology in Lodpr/lncRNA-HSVIII Knockout Mice with Advancing Age.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- Male specific conserved LncRNA TSCL1 regulated target mRNA translation by interaction with PIWIL1.Cell death and differentiation · 2026Article
- Identification of lncRNA expression profiles associated with ovarian development and ageing process in mice.Journal of applied genetics · 2025Article
- Gene regulation by non-Coding RNAs in infertility: a mechanistic review.Journal of ovarian research · 2025Review
- The lncRNA41584-miR3047-z-Insects · 2025Article
- Xist condensates: perspectives for therapeutic intervention.Genome biology · 2025Review
- Mechanisms of Hormonal, Genetic, and Temperature Regulation of Germ Cell Proliferation, Differentiation, and Death During Spermatogenesis.Biomolecules · 2025Review
- Human sperm RNA in male infertility.Nature reviews. Urology · 2025Review
- Exploring the Characters of Non-Coding RNAs in Spermatogenesis and Male Infertility.International journal of molecular sciences · 2025Review
- The Role of Long Intergenic Noncoding RNA in Fetal Development.International journal of molecular sciences · 2024Review
- Uncovering a multitude of stage-specific splice variants and putative protein isoforms generated along mouse spermatogenesis.BMC genomics · 2024Article
- Orchestrating Asymmetric Expression: Mechanisms behindEpigenomes · 2024Review
- LncRNA Functional Screening in Organismal Development.Non-coding RNA · 2023Review
- Towards a Multi-Omics of Male Infertility.The world journal of men's health · 2023Review
- Genome-Wide Landscape of mRNAs, lncRNAs, and circRNAs during Testicular Development of Yak.International journal of molecular sciences · 2023Article
- Epigenetic Reprogramming and Somatic Cell Nuclear Transfer.Methods in molecular biology (Clifton, N.J.) · 2023Review
- The long non-coding RNA transcript, LOC100130460 (CAND1.11) gene, encodes a novel protein highly expressed in cancer cells and tumor human testis tissues.Cancer biomarkers : section A of Disease markers · 2023Article
- Inversion of a topological domain leads to restricted changes in its gene expression and affects interdomain communication.Development (Cambridge, England) · 2022Article
- Evidence for a functional role of Start, a long noncoding RNA, in mouse spermatocytes.PloS one · 2022Article
40 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The Tsx gene resides at the X-inactivation center and is thought to encode a protein expressed in testis, but its function has remained mysterious. Given its proximity to noncoding genes that regulate X-inactivation, here we characterize Tsx and determine its function in mice. We find that Tsx is actually noncoding and the long transcript is expressed robustly in meiotic germ cells, embryonic stem cells, and brain. Targeted deletion of Tsx generates viable offspring and X-inactivation is only mildly affected in embryonic stem cells. However, mutant embryonic stem cells are severely growth-retarded, differentiate poorly, and show elevated cell death. Furthermore, male mice have smaller testes resulting from pachytene-specific apoptosis and a maternal-specific effect results in slightly smaller litters. Intriguingly, male mice lacking Tsx are less fearful and have measurably enhanced hippocampal short-term memory. Combined, our study indicates that Tsx performs general functions in multiple cell types and links the noncoding locus to stem and germ cell development, learning, and behavior in mammals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.