ArticleInternational journal of biological sciences2011
Identification of candidate genes related to bovine marbling using protein-protein interaction networks.
Article in International journal of biological sciences, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
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- Genome-Wide Association Study of Maternal Genetic Effects on Intramuscular Fat and Fatty Acid Composition in Rabbits.Animals : an open access journal from MDPI · 2023Article
- Vetinformatics from functional genomics to drug discovery: Insights into decoding complex molecular mechanisms of livestock systems in veterinary science.Frontiers in veterinary science · 2022Review
- Effects of the association between whole cottonseed and calcium salts of fatty acids on nutrient intake, feedlot performance, and carcass characteristics ofTranslational animal science · 2021Article
- Analyzing host-viral interactome of SARS-CoV-2 for identifying vulnerable host proteins during COVID-19 pathogenesis.Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases · 2021Article
- Omega-6 Fatty Acids: A Sustainable Alternative to Improve Beef Production Efficiency.Animals : an open access journal from MDPI · 2021Review
- Genomic Approaches Reveal Pleiotropic Effects in Crossbred Beef Cattle.Frontiers in genetics · 2021Article
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- Use of gene expression and whole-genome sequence information to improve the accuracy of genomic prediction for carcass traits in Hanwoo cattle.Genetics, selection, evolution : GSE · 2020Article
- Supplementing Ca salts of soybean oil to late-gestating beef cows: impacts on performance and physiological responses of the offspring.Journal of animal science · 2020Article
- Effects of fatty acid profile of supplements on intake, performance, carcass traits, meat characteristics, and meat sensorial analysis of feedlotTranslational animal science · 2020Article
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- Effect of Dietary Rumen-Protected L-Tryptophan Supplementation on Growth Performance, Blood Hematological and Biochemical Profiles, and Gene Expression in Korean Native Steers under Cold Environment.Animals : an open access journal from MDPI · 2019Article
- Supplementing calcium salts of soybean oil to beef steers early in life to enhance carcass development and quality1.Journal of animal science · 2019Article
- Adipogenic/lipogenic gene expression and fatty acid composition in chuck, loin, and round muscles in response to grain feeding of Yanbian Yellow cattle.Journal of animal science · 2018Article
- Differential regulation of mRNAs and lncRNAs related to lipid metabolism in two pig breeds.Oncotarget · 2017Article
- Global transcriptome analysis identifies differentially expressed genes related to lipid metabolism in Wagyu and Holstein cattle.Scientific reports · 2017Article
- Article
- Large-scale gene co-expression network as a source of functional annotation for cattle genes.BMC genomics · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex traits are determined by the combined effects of many loci and are affected by gene networks or biological pathways. Systems biology approaches have an important role in the identification of candidate genes related to complex diseases or traits at the system level. The present study systemically analyzed genes associated with bovine marbling score and identified their relationships. The candidate nodes were obtained using MedScan text-mining tools and linked by protein-protein interaction (PPI) from the Human Protein Reference Database (HPRD). To determine key node of marbling, the degree and betweenness centrality (BC) were used. The hub nodes and biological pathways of our network are consistent with the previous reports about marbling traits, and also suggest unknown candidate genes associated with intramuscular fat. Five nodes were identified as hub genes, which was consistent with the network analysis using quantitative reverse-transcription PCR (qRT-PCR). Key nodes of the PPI network have positive roles (PPARγ, C/EBPα, and RUNX1T1) and negative roles (RXRA, CAMK2A) in the development of intramuscular fat by several adipogenesis-related pathways. This study provides genetic information for identifying candidate genes for the marbling trait in bovine.
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