Evidence map›Paper›PMID 21912487›Full record

ArticleInternational journal of nephrology and renovascular disease2011

Validity of urinary monoamine assay sales under the "spot baseline urinary neurotransmitter testing marketing model".

Marty Hinz, Alvin Stein, Thomas Uncini

RetractedAbstract readRetracted Publication
In one paragraph

Article in International journal of nephrology and renovascular disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Parkinson's disease managing reversible neurodegeneration.Neuropsychiatric disease and treatment · 2016
    Article
  2. Article
  3. Parkinson's disease: carbidopa, nausea, and dyskinesia.Clinical pharmacology : advances and applications · 2014
    Article
  4. Review
  5. Article
  6. 5-HTP efficacy and contraindications.Neuropsychiatric disease and treatment · 2012
    Article
  7. Article
  8. The discrediting of the monoamine hypothesis.International journal of general medicine · 2012
    Article
  9. Article
  10. Monoamine depletion by reuptake inhibitors.Drug, healthcare and patient safety · 2011
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Marty HinzClinical Research, Neuro Research Clinics Inc, Cape Coral, FL;
Alvin Stein
Thomas Uncini

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spot baseline urinary monoamine assays have been used in medicine for over 50 years as a screening test for monoamine-secreting tumors, such as pheochromocytoma and carcinoid syndrome. In these disease states, when the result of a spot baseline monoamine assay is above the specific value set by the laboratory, it is an indication to obtain a 24-hour urine sample to make a definitive diagnosis. There are no defined applications where spot baseline urinary monoamine assays can be used to diagnose disease or other states directly. No peer-reviewed published original research exists which demonstrates that these assays are valid in the treatment of individual patients in the clinical setting. Since 2001, urinary monoamine assay sales have been promoted for numerous applications under the "spot baseline urinary neurotransmitter testing marketing model". There is no published peer-reviewed original research that defines the scientific foundation upon which the claims for these assays are made. On the contrary, several articles have been published that discredit various aspects of the model. To fill the void, this manuscript is a comprehensive review of the scientific foundation and claims put forth by laboratories selling urinary monoamine assays under the spot baseline urinary neurotransmitter testing marketing model.

Indexed as

dopamineepinephrinemonoaminenorepinephrineserotoninurinaryurine

Identifiers

PMID21912487
PMCPMC3165907

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.