ArticleMaterials science & engineering. C, Materials for biological applications2011
Bioactive glass scaffolds for bone tissue engineering: state of the art and future perspectives.
Article in Materials science & engineering. C, Materials for biological applications, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
115 citing papers in PubMed.
- Berberine-Loaded Mesoporous Bioactive Glass Enhances Bone Repair through Combined Immunomodulatory and Osteogenic Effects.ACS omega · 2026Article
- Strategic Placement of Pores to Modulate Toughness in Hydroxyapatite Bone Scaffolds Fixation.Biomimetics (Basel, Switzerland) · 2026Article
- Ex vivo engineering of neural tissue structure and growth using sequential 2D and 3D solid scaffolds.In vitro cellular & developmental biology. Animal · 2026Article
- Optimal Selection of Biodegradable Polymer Composites for Load-Bearing Bone Tissue Engineering: A Hybrid Fuzzy AHP-TOPSIS Framework with Sensitivity-Based Robustness Analysis.Journal of functional biomaterials · 2026Article
- Indirect 3D printing in tissue engineering: expanding materials used for improved scaffold functionality.Biomedical engineering online · 2025Review
- Biofunctionalization of Stem Cell Scaffold for Osteogenesis and Bone Regeneration.Biomolecules · 2025Review
- Recent advances in hydrogel-assisted treatment of malignant bone tumors.Materials today. Bio · 2025Review
- Unraveling osteogenesis mechanisms of the empowered VitaFlux adaptive regeneration biomaterials for bone tissue engineering: Insights into the role of BBGs/BSBGs.Bioactive materials · 2025Review
- In Vivo Performance of a Novel Hyper-Crosslinked Carbohydrate Polymer Bone Graft Substitute for Spinal Fusion.Bioengineering (Basel, Switzerland) · 2025Article
- Glasses for bone regeneration: structural features controlling physical properties and ion release of bioactive glasses 45S5, S53P4 and 13-93.RSC advances · 2025Article
- Fluorapatite Glass-Ceramics in Dentistry: Synthesis, Properties, Forming Technology, Applications, Challenges, and Future Perspectives.Materials (Basel, Switzerland) · 2025Review
- Insights into Calcium Phosphate Formation Induced by the Dissolution of 45S5 Bioactive Glass.ACS biomaterials science & engineering · 2025Article
- Biomaterial Cues for Regulation of Osteoclast Differentiation and Function in Bone Regeneration.Advanced therapeutics · 2025Article
- Piezoelectricity of hexagonal boron nitrides improves bone tissue generation as tested on osteoblasts.Beilstein journal of nanotechnology · 2025Article
- An Enhanced Bioactive Glass Composition with Improved Thermal Stability and Sinterability.Materials (Basel, Switzerland) · 2024Article
- Functionalization of 3D printed poly(lactic acid)/graphene oxide/β-tricalcium phosphate (PLA/GO/TCP) scaffolds for bone tissue regeneration application.RSC advances · 2024Article
- Bone scaffolds-based localized drugs delivery for osteosarcoma: current status and future perspective.Drug delivery · 2024Review
- Advances in Bioceramics for Bone Regeneration: A Narrative Review.Biomimetics (Basel, Switzerland) · 2024Review
- Research on Dual-Phase Composite Forming Process and Platform Construction of Radial Gradient Long Bone Scaffold.Bioengineering (Basel, Switzerland) · 2024Article
- In vitro and in vivo dissolution of biocompatible S59 glass scaffolds.Journal of materials science. Materials in medicine · 2024Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The repair and regeneration of large bone defects resulting from disease or trauma remains a significant clinical challenge. Bioactive glass has appealing characteristics as a scaffold material for bone tissue engineering, but the application of glass scaffolds for the repair of load-bearing bone defects is often limited by their low mechanical strength and fracture toughness. This paper provides an overview of recent developments in the fabrication and mechanical properties of bioactive glass scaffolds. The review reveals the fact that mechanical strength is not a real limiting factor in the use of bioactive glass scaffolds for bone repair, an observation not often recognized by most researchers and clinicians. Scaffolds with compressive strengths comparable to those of trabecular and cortical bones have been produced by a variety of methods. The current limitations of bioactive glass scaffolds include their low fracture toughness (low resistance to fracture) and limited mechanical reliability, which have so far received little attention. Future research directions should include the development of strong and tough bioactive glass scaffolds, and their evaluation in unloaded and load-bearing bone defects in animal models.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.