ArticleThe Journal of clinical investigation2011
Inflammatory dendritic cells migrate in and out of transplanted chronic mycobacterial granulomas in mice.
Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 54 citations in OpenAlex.
- Age-related neuroimmune signatures in dorsal root ganglia of a Fabry disease mouse model.Immunity & ageing : I & A · 2023Article
- Understanding the tuberculosis granuloma: the matrix revolutions.Trends in molecular medicine · 2022Review
- Pathological and protective roles of dendritic cells inFrontiers in cellular and infection microbiology · 2022Review
- Current concepts in granulomatous immune responses.Biologia futura · 2021Review
- Reconsidering the Optimal Immune Response toAmerican journal of respiratory and critical care medicine · 2020Article
- Adjuvant-free immunization with infective filarial larvae as lymphatic homing antigen carriers.Scientific reports · 2020Article
- Review
- In Vitro Granuloma Models of Tuberculosis: Potential and Challenges.The Journal of infectious diseases · 2019Review
- Inflammatory Dendritic Cells, Regulated by IL-4 Receptor Alpha Signaling, Control Replication, and Dissemination ofFrontiers in cellular and infection microbiology · 2019Article
- CCR7 deficient inflammatory Dendritic Cells are retained in the Central Nervous System.Scientific reports · 2017Article
- Divergent Functions of TLR2 on Hematopoietic and Nonhematopoietic Cells during Chronic Mycobacterium tuberculosis Infection.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Macrophage form, function, and phenotype in mycobacterial infection: lessons from tuberculosis and other diseases.Pathogens and disease · 2016Review
- Mycobacterium tuberculosis exploits the formation of new blood vessels for its dissemination.Scientific reports · 2016Article
- Pathology and immune reactivity: understanding multidimensionality in pulmonary tuberculosis.Seminars in immunopathology · 2016Review
- Stimulation through CD40 and TLR-4 Is an Effective Host Directed Therapy againstFrontiers in immunology · 2016Article
- Mycobacterium-Infected Dendritic Cells Disseminate Granulomatous Inflammation.Scientific reports · 2015Article
- Lymphangiogenesis is induced by mycobacterial granulomas via vascular endothelial growth factor receptor-3 and supports systemic T-cell responses against mycobacterial antigen.The American journal of pathology · 2015Article
- The balance between protective and pathogenic immune responses in the TB-infected lung.Nature immunology · 2015Review
- Immunity and Immunopathology in the Tuberculous Granuloma.Cold Spring Harbor perspectives in medicine · 2014Review
- Immunophenotype in orofacial granulomatosis with and without Crohn's disease.Medicina oral, patologia oral y cirugia bucal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
An estimated one-third of the world's population is infected with Mycobacterium tuberculosis, although most affected individuals maintain a latent infection. This control is attributed to the formation of granulomas, cell masses largely comprising infected macrophages with T cells aggregated around them. Inflammatory DCs, characterized as CD11c+CD11b+Ly6C+, are also found in granulomas and are an essential component of the acute immune response to mycobacteria. However, their function during chronic infection is less well understood. Here, we report that CD11c+ cells dynamically traffic in and out of both acute and chronic granulomas induced by Mycobacterium bovis strain bacillus Calmette-Guérin (BCG) in mice. By transplanting Mycobacterium-induced granulomas containing fluorescently labeled CD11c+ cells and bacteria into unlabeled mice, we were able to follow CD11c+ cell trafficking and T cell activation. We found that half of the CD11c+ cells in chronic granulomas were exchanged within 1 week. Compared with tissue-resident DC populations, CD11c+ cells migrating out of granuloma-containing tissue had an unexpected systemic dissemination pattern. Despite low antigen availability, systemic CD4+ T cell priming still occurred during chronic infection. These data demonstrate that surveillance of granulomatous tissue by CD11c+ cells is continuous and that these cells are distinct from tissue-resident DC populations and support T cell priming during both stages of Mycobacterium infection. This intense DC surveillance may also be a feature of Mycobacterium tuberculosis infection and other granuloma-associated diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.