ArticleBlood2011
Warfarin and acetaminophen interaction: a summary of the evidence and biologic plausibility.
Article in Blood, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Use of tramadol and the risk of bleeding complications in patients on oral anticoagulants: a systematic review and meta-analysis.European journal of clinical pharmacology · 2022Pooled it
- Criteria for assessing high-priority drug-drug interactions for clinical decision support in electronic health records.BMC medical informatics and decision making · 2013Pooled it
- Evaluation of Prothrombin Time and Activated Partial Thromboplastin Time in Antithrombotic-Treated Cardiac Patients: A Cross-Sectional Study from Sana'a City, Yemen.Vascular health and risk management · 2026Article
- The association between warfarin usage and international normalized ratio increase: systematic analysis of FDA Adverse Event Reporting System (FAERS).The journal of cardiovascular aging · 2023Article
- A Case of Unexplained Warfarin Resistance: A Case Report and Literature Review.The journal of Tehran Heart Center · 2023Article
- Ultrasound-guided injection with hyaluronic acid in hip osteoarthritis: efficacy and safety in a real-life setting.Clinical rheumatology · 2022Article
- Clinical and surgical outcomes of splenectomy for autoimmune hemolytic anemia.Surgical endoscopy · 2022Article
- Warfarin and acetaminophen interaction in a 47-year-old woman.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2020Article
- Identification of environmental and genetic factors that influence warfarin time in therapeutic range.Genetics and molecular biology · 2020Article
- A case of a warfarinized renal cancer patient monitored for prothrombin time-international normalized ratio during methadone introduction.JA clinical reports · 2017Article
- Factors influencing warfarin response in hospitalized patients.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2015Article
- Cytochrome P450 interactions and clinical implication in rheumatology.Clinical rheumatology · 2014Review
- Drug-drug interactions and risk of bleeding among inpatients on warfarin therapy: a prospective observational study.Thrombosis journal · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Ms TS is a 66-year-old woman who receives warfarin for prevention of systemic embolization in the setting of hypertension, diabetes, and atrial fibrillation. She had a transient ischemic attack about 4 years ago when she was receiving aspirin. Her INR control was excellent; however, over the past few months it has become erratic, and her average dose required to maintain an INR of 2.0 to 3.0 appears to have decreased. She has had back pain over this same period and has been taking acetaminophen at doses at large as 650 mg four times daily, with her dose varying based on her symptoms. You recall a potential interaction and wonder if (1) her acetaminophen use is contributing to her loss of INR control, and (2) does this interaction place her at increased risk of warfarin-related complications?
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.