ArticleCirculation2011
Thrombomodulin gene variants are associated with increased mortality after coronary artery bypass surgery in replicated analyses.
Article in Circulation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- A donor thrombomodulin gene variation predicts graft-versus-host disease development and mortality after bone marrow transplantation.International journal of hematology · 2015Trial
- Association between CRP rs1800947 genotypes, dexamethasone use, postoperative CRP level and morbidity in adult cardiac surgical patients in post-hoc analysis of the observational INFLACOR cohort trial.Scientific reports · 2026Observational
- Genome-wide association study-driven identification of thrombomodulin and factor V as the best biomarker combination for deep vein thrombosis.Genomics & informatics · 2025Article
- Identification and Validation of Diagnostic Model Based on Angiogenesis- and Epithelial Mesenchymal Transition-Related Genes in Myocardial Infarction.International journal of general medicine · 2024Article
- The synergistic effect of the triglyceride-glucose index and serum uric acid on the prediction of major adverse cardiovascular events after coronary artery bypass grafting: a multicenter retrospective cohort study.Cardiovascular diabetology · 2023Article
- Association study of polymorphism in Thrombomodulin gene [rs1042579] with cardiovascular disease.Acta bio-medica : Atenei Parmensis · 2022Article
- Quality Control Measures and Validation in Gene Association Studies: Lessons for Acute Illness.Shock (Augusta, Ga.) · 2020Review
- Differences in Expression of Genes Involved in Bone Development and Morphogenesis in the Walls of Internal Thoracic Artery and Saphenous Vein Conduits May Provide Markers Useful for Evaluation Graft Patency.International journal of molecular sciences · 2019Article
- Article
- Association of Thrombomodulin Gene C1418T Polymorphism with Susceptibility to Kawasaki Disease in Chinese Children.Disease markers · 2018Article
- Common Variant in Glycoprotein Ia Increases Long-Term Adverse Events Risk After Coronary Artery Bypass Graft Surgery.Journal of the American Heart Association · 2016Article
- Thrombomodulin gene c.1418C>T polymorphism and risk of recurrent venous thromboembolism.Journal of thrombosis and thrombolysis · 2016Article
- Interleukin-1β gene variants are associated with QTc interval prolongation following cardiac surgery: a prospective observational study.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2016Observational
- Platelet Counts, Acute Kidney Injury, and Mortality after Coronary Artery Bypass Grafting Surgery.Anesthesiology · 2016Article
- Genome-wide association study of acute kidney injury after coronary bypass graft surgery identifies susceptibility loci.Kidney international · 2015Article
- Genome-wide association study of perioperative myocardial infarction after coronary artery bypass surgery.BMJ open · 2015Article
- Biomarkers in Coronary Artery Bypass Surgery: Ready for Prime Time and Outcome Prediction?Frontiers in cardiovascular medicine · 2015Review
- G protein-coupled receptor kinase 5 gene polymorphisms are associated with postoperative atrial fibrillation after coronary artery bypass grafting in patients receiving β-blockers.Circulation. Cardiovascular genetics · 2014Article
- Polymorphisms in glutathione S-transferase are risk factors for perioperative acute myocardial infarction after cardiac surgery: a preliminary study.Molecular and cellular biochemistry · 2014Article
- Genetics of coronary artery disease.Circulation · 2013Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe tested the hypothesis that genetic variation in thrombotic and inflammatory pathways is independently associated with long-term mortality after coronary artery bypass graft (CABG) surgery. METHODS AND
resultsTwo separate cohorts of patients undergoing CABG surgery at a single institution were examined, and all-cause mortality between 30 days and 5 years after the index CABG was ascertained from the National Death Index. In a discovery cohort of 1018 patients, a panel of 90 single-nucleotide polymorphisms (SNPs) in 49 candidate genes was tested with Cox proportional hazard models to identify clinical and genomic multivariate predictors of incident death. After adjustment for multiple comparisons and clinical predictors of mortality, the homozygote minor allele of a common variant in the thrombomodulin (THBD) gene (rs1042579) was independently associated with significantly increased risk of all-cause mortality (hazard ratio, 2.26; 95% CI, 1.31 to 3.92; P=0.003). Six tag SNPs in the THBD gene, 1 of which (rs3176123) in complete linkage disequilibrium with rs1042579, were then assessed in an independent validation cohort of 930 patients. After multivariate adjustment for the clinical predictors identified in the discovery cohort and multiple testing, the homozygote minor allele of rs3176123 independently predicted all-cause mortality (hazard ratio, 3.6; 95% CI, 1.67 to 7.78; P=0.001).
conclusionsIn 2 independent cardiac surgery cohorts, linked common allelic variants in the THBD gene are independently associated with increased long-term mortality risk after CABG and significantly improve the classification ability of traditional postoperative mortality prediction models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.