SynthesisDiabetes2011
CPVL/CHN2 genetic variant is associated with diabetic retinopathy in Chinese type 2 diabetic patients.
Synthesis in Diabetes, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Connections Between Gene Polymorphism and Fetlock and Hock Measurements in Polish Sport Horses.International journal of molecular sciences · 2025Article
- β2-Chimaerin, a GTPase-Activating Protein for Rac1, Is a Novel Regulator of Hepatic Insulin Signaling and Glucose Metabolism.Molecules (Basel, Switzerland) · 2024Article
- Carboxypeptidase vitellogenic like facilitates resistance to CDK4/6 inhibitors in breast cancer.Thoracic cancer · 2023Article
- CPVL promotes glioma progression via STAT1 pathway inhibition through interactions with the BTK/p300 axis.JCI insight · 2021Article
- Lack of association of genetic variants for diabetic retinopathy in Taiwanese patients with diabetic nephropathy.BMJ open diabetes research & care · 2020Article
- Article
- Unraveling the role of genetics in the pathogenesis of diabetic retinopathy.Eye (London, England) · 2019Review
- CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes.Scientific reports · 2017Article
- Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity.BMC genomics · 2017Article
- Candidate gene studies of diabetic retinopathy in human.Molecular biology reports · 2016Review
- Novel Gene Expression Signature Predictive of Clinical Recurrence After Radical Prostatectomy in Early Stage Prostate Cancer Patients.The Prostate · 2016Article
- Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy.BMC medicine · 2015Article
- TOX and CDKN2A/B Gene Polymorphisms Are Associated with Type 2 Diabetes in Han Chinese.Scientific reports · 2015Article
- The association of previously reported polymorphisms for microvascular complications in a meta-analysis of diabetic retinopathy.Human genetics · 2015Review
- FRMD3 gene: its role in diabetic kidney disease. A narrative review.Diabetology & metabolic syndrome · 2015Review
- Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes.Journal of diabetes research · 2015Article
- Meta-analysis of association between K469E polymorphism of the ICAM-1 gene and retinopathy in type 2 diabetes.International journal of ophthalmology · 2015Article
- Challenges in elucidating the genetics of diabetic retinopathy.JAMA ophthalmology · 2014Review
- From single nucleotide polymorphism to transcriptional mechanism: a model for FRMD3 in diabetic nephropathy.Diabetes · 2013Article
- Diabetic nephropathy: FRMD3 in diabetic nephropathy--guilt by association.Nature reviews. Nephrology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveDiabetic nephropathy and retinopathy are two important microvascular diabetes complications with a high concordance rate in diabetic patients. A recent genome-wide association study in type 1 diabetic patients of European descent identified four loci to be associated with diabetic nephropathy. The aim of this study was to test the effects of single nucleotide polymorphisms (SNPs) from these four loci on diabetic nephropathy and retinopathy in Chinese type 2 diabetic patients. RESEARCH DESIGN AND
methodsIn stage 1, we recruited 1,276 type 2 diabetic patients, including 378 patients with diabetic nephropathy but no retinopathy, 374 patients with diabetic retinopathy but no nephropathy, 244 patients with both diabetic retinopathy and nephropathy, and 280 control subjects with diabetes for >10 years and no diabetic retinopathy or nephropathy. Fifty-five SNPs from four loci (CPVL/CHN2, FRMD3, CARS, and IRS2) were genotyped. The SNPs that showed associations to diabetic retinopathy or nephropathy were genotyped in stage 2 samples for replication.
resultsSNPs from CPVL/CHN2 and FRMD3 were associated with diabetic retinopathy with rs39059 and rs10868025 as the top SNPs (odds ratio [OR] 1.292, 95% CI 1.097-1.523, P = 0.0022, for rs39059; 1.201, 1.014-1.422, P = 0.0343, for rs10868025) in stage 1 samples. In stage 2 analysis, only rs39059 showed similar effect to diabetic retinopathy (OR 1.269, 0.989-1.628, P = 0.0689), and meta-analysis showed a significant association between rs39059 and diabetic retinopathy, with an OR of 1.285 (1.120-1.474, P = 0.0003). CPVL/CHN2 rs39059 was also associated with levels of diabetic retinopathy (P = 0.0007 for trend). However, no association was detected between these SNPs and diabetic nephropathy.
conclusionsIn this study, we found CPVL/CHN2 rs39059 was associated with diabetic retinopathy in the Chinese type 2 diabetic patients.
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