ArticleMolecular cancer research : MCR2011
SDF-1α induces PDGF-B expression and the differentiation of bone marrow cells into pericytes.
Article in Molecular cancer research : MCR, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- CXCR3-CXCL11 Signaling Restricts Angiogenesis and Promotes Pericyte Recruitment.Arteriosclerosis, thrombosis, and vascular biology · 2024Article
- CXCR3-CXCL11 signaling restricts angiogenesis and promotes pericyte recruitment.bioRxiv : the preprint server for biology · 2023Article
- Loss of CEACAM1 in endothelial cells causes hepatic fibrosis.Metabolism: clinical and experimental · 2023Article
- A SOX17-PDGFB signaling axis regulates aortic root development.Nature communications · 2022Article
- Exercise Inhibits Doxorubicin-Induced Damage to Cardiac Vessels and Activation of Hippo/YAP-Mediated Apoptosis.Cancers · 2021Article
- Chemokine mediated signalling within arteries promotes vascular smooth muscle cell recruitment.Communications biology · 2020Article
- The CXCR4 antagonist plerixafor (AMD3100) promotes proliferation of Ewing sarcoma cell lines in vitro and activates receptor tyrosine kinase signaling.Cell communication and signaling : CCS · 2018Article
- The chemokines CXCL12 and CXCL14 differentially regulate connective tissue markers during limb development.Scientific reports · 2017Article
- Escaping Antiangiogenic Therapy: Strategies Employed by Cancer Cells.International journal of molecular sciences · 2016Review
- Endoglin regulates mural cell adhesion in the circulatory system.Cellular and molecular life sciences : CMLS · 2016Article
- Role of microglial m1/m2 polarization in relapse and remission of psychiatric disorders and diseases.Pharmaceuticals (Basel, Switzerland) · 2014Review
- Blocking SDF-1α/CXCR4 downregulates PDGF-B and inhibits bone marrow-derived pericyte differentiation and tumor vascular expansion in Ewing tumors.Molecular cancer therapeutics · 2014Article
- Trim14 overexpression causes the same transcriptional changes in mouse embryonic stem cells and human HEK293 cells.In vitro cellular & developmental biology. Animal · 2014Article
- Comprehensive genomic profiling in diabetic nephropathy reveals the predominance of proinflammatory pathways.Physiological genomics · 2013Article
- Article
- Resistance and escape from antiangiogenesis therapy: clinical implications and future strategies.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2012Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Platelet-derived growth factor B (PDGF-B) and its receptor, PDGFR-β, play a critical role in pericyte maturation; however, the mechanisms by which PDGF-B is upregulated in the tumor microenvironment remain unclear. We previously showed that upregulating stromal-derived factor, SDF-1α, in VEGF(165)-inhibited Ewing's sarcoma tumors (TC/siVEGF(7-1)) induced PDGF-B mRNA expression, increased infiltration and differentiation of bone marrow cells (BMC) into pericytes and, rescued tumor growth. The purpose of this study was to investigate the mechanism by which SDF-1α increased PDGF-B expression and the role of this pathway in BM-derived pericyte differentiation. We showed that SDF-1α induced expression of PDGF-B mRNA and protein both in vitro and in vivo. In contrast, inhibiting SDF-1α downregulated PDGF-B. We cloned the 2-kb pdgf-b promoter fragment and showed that SDF-1α activates PDGF-B via a transcriptional mechanism. Chromatin immunoprecipitation showed that the ELK-1 transcription factor binds to the pdgf-b promoter in response to SDF-1α. We confirmed the correlation between the SDF-1α/PDGF-B pathway and the differentiation of PDGFR-β+ BMCs into mature pericytes using an in vitro assay. These findings show that SDF-1α regulates PDGF-B expression and that this regulation plays a critical role in the differentiation of PDGFR-β+ BMCs into mature pericytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.