ArticleHypertension (Dallas, Tex. : 1979)2011
Role of T lymphocytes in angiotensin II-mediated microvascular thrombosis.
Article in Hypertension (Dallas, Tex. : 1979), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 39 citations in OpenAlex.
- Article
- Endoplasmic Reticulum Stress in Hypertension and Salt Sensitivity of Blood Pressure.Current hypertension reports · 2024Review
- Alveolar Hyperoxia and Exacerbation of Lung Injury in Critically Ill SARS-CoV-2 Pneumonia.Medical sciences (Basel, Switzerland) · 2023Review
- Advances in the Role of Endothelial Cells in Cerebral Small Vessel Disease.Frontiers in neurology · 2022Review
- Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms.Mayo Clinic proceedings · 2021Review
- Coagulation abnormalities in SARS-CoV-2 infection: overexpression tissue factor.Thrombosis journal · 2020Review
- COVID-19 as a viral functional ACE2 deficiency disorder with ACE2 related multi-organ disease.Medical hypotheses · 2020Article
- Age-related cerebral small vessel disease and inflammaging.Cell death & disease · 2020Review
- Splenocyte transfer exacerbates salt-sensitive hypertension in rats.Experimental physiology · 2020Article
- Novel Role of T Cells and IL-6 (Interleukin-6) in Angiotensin II-Induced Microvascular Dysfunction.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Angiotensin II Signal Transduction: An Update on Mechanisms of Physiology and Pathophysiology.Physiological reviews · 2018Review
- Loss of Resistance to Angiotensin II-Induced Hypertension in the Jackson Laboratory Recombination-Activating Gene Null Mouse on the C57BL/6J Background.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Possible role of lymphocytes in glucocorticoid-induced increase in trabecular bone mineral density.The Journal of endocrinology · 2015Article
- Functional aortic stiffness: role of CD4(+) T lymphocytes.Frontiers in physiology · 2015Article
- Spontaneous white matter damage, cognitive decline and neuroinflammation in middle-aged hypertensive rats: an animal model of early-stage cerebral small vessel disease.Acta neuropathologica communications · 2014Article
- Roles of Coagulation and fibrinolysis in angiotensin II-enhanced microvascular thrombosis.Microcirculation (New York, N.Y. : 1994) · 2014Article
- Dual opposing roles of adaptive immunity in hypertension.European heart journal · 2014Review
- Interleukin-6-signal transducer and activator of transcription-3 signaling mediates aortic dissections induced by angiotensin II via the T-helper lymphocyte 17-interleukin 17 axis in C57BL/6 mice.Arteriosclerosis, thrombosis, and vascular biology · 2013Article
- VDR hypermethylation and HIV-induced T cell loss.Journal of leukocyte biology · 2013Article
- ACE2-Ang-(1-7)-Mas Axis in Brain: A Potential Target for Prevention and Treatment of Ischemic Stroke.Current neuropharmacology · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Clinical trials and animal studies have revealed a role for the renin-angiotensin system in the enhanced thrombus development that is associated with hypertension. Because T lymphocytes have been implicated in the vascular dysfunction and blood pressure elevation associated with increased angiotensin II (Ang II) levels, we evaluated the role of the adaptive immune system in mediating the enhanced thrombosis during Ang II-induced hypertension. Light/dye-induced thrombosis was induced in cremaster arterioles of wild-type, immunodeficient Rag-1(-/-), CD8(+), or CD4(+) lymphocyte-deficient and NADPH oxidase (gp91(phox))-deficient mice implanted with an Ang II-loaded pump for 2 weeks. Chronic Ang II infusion enhanced arteriolar thrombosis in wild-type mice but not in Rag-1(-/-), CD4(+) T-cell-deficient, or gp91(phox-/-) mice. CD8(+) T-cell(-/-) mice exhibited partial protection. Adoptive transfer of T cells derived from wild-type or gp91(phox-/-) mice into Rag-1(-/-) restored the prothrombotic phenotype induced by Ang II. T lymphocytes (CD4(+) and, to a lesser extent, CD8(+)) play a major role in mediating the accelerated microvascular thrombosis associated with Ang II-induced hypertension. NADPH oxidase-derived reactive oxygen species, produced by cells other than T lymphocytes, also appear critical for the Ang II-enhanced, T cell-dependent thrombosis response.
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