Evidence map›Paper›PMID 21911708›Full record

ArticleHypertension (Dallas, Tex. : 1979)2011

Progression is accelerated from prehypertension to hypertension in blacks.

Anbesaw Selassie, C Shaun Wagner, Marilyn L Laken, M LaFrance Ferguson, Keith C Ferdinand, Brent M Egan

Registry-linked trialAbstract readComparative StudyMulticenter Study
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02830529 (Mindfulness Attitude to Deliver Dietary Approach to Stop Hypertension), which is not on this map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02830529 nacompletednot on this mapstarted 2015, after this paper: background citation

Mindfulness Attitude to Deliver Dietary Approach to Stop Hypertension

TypeinterventionalSponsorCase Western Reserve UniversityRan2015 to 2017Enrolled31ConditionsPrehypertensionArmsMAD DASH, DASH diet education
3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Evening versus morning dosing regimen drug therapy for hypertension.The Cochrane database of systematic reviews · 2024
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4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Anbesaw SelassieDivision of Biostatistics, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. selassie@musc.edu
C Shaun Wagner
Marilyn L Laken
M LaFrance Ferguson
Keith C Ferdinand
Brent M Egan

Funding

SOUTH CAROLINA CLINICAL & TRANSLATIONAL RESEARCH INSTITUTE (SCTR)UL1RR029882 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2009 to 2011
$10.1M
A collaborative model to improve BP control and minimize racial disparities-CCCR01HL091841 · NHLBI · UNIVERSITY OF IOWA · PI CARTER, BARRY L · 2009 to 2013
$4.7M
Improving safety and access for physical activity supplementR01DK067615 · NIDDK · UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA · PI WILSON, DAWN K · 2007 to 2010
$3.2M
NCRR NIH HHS 1UL1RR029882NCRR NIH HHS UL1 RR029882NHLBI NIH HHS HL091841NHLBI NIH HHS R01 HL091841NIDDK NIH HHS DK067615NIDDK NIH HHS R01 DK067615
6 · The paper itself

Abstract

Prehypertension is a major risk factor for hypertension. Blacks have more prevalent and severe hypertension than whites, but it is unknown whether progression from prehypertension is accelerated in blacks. We examined this question in a prospective cohort study of 18 865 nonhypertensive persons (5733 black [30.4%] and 13 132 white [69.6%]) aged 18 to 85 years. Electronic health record data were obtained from 197 community-based outpatient clinics in the Southeast United States. Days elapsing from study entry to hypertension diagnosis, mainly blood pressure ≥140 mm Hg systolic and/or ≥90 mm Hg diastolic on 2 consecutive visits established conversion time within a maximum observation period of 2550 days. Cox regression modeling was used to examine conversion to hypertension as a function of race, while controlling for age, sex, baseline systolic and diastolic blood pressures, body mass index, diabetes mellitus, and chronic kidney disease. The covariable adjusted median conversion time when 50% became hypertensive was 365 days earlier for blacks than whites (626 versus 991 days; P<0.001). Among covariables, baseline systolic blood pressure 130 to 139 mm Hg (hazard ratio: 1.77 [95% CI: 1.69 to 1.86]) and 120 to 129 mm Hg (hazard ratio: 1.52 [95% CI: 1.44 to 1.60]), as well as age ≥75 years (hazard ratio: 1.40 [95% CI: 1.29 to 1.51]) and 55 to 74 years (hazard ratio: 1.29 [95% CI: 1.23 to 1.35]) were the strongest predictors of hypertension. Additional predictors included age 35 to 54 years, diastolic blood pressure 80 to 89 mm Hg, overweight and obesity, and diabetes mellitus (all P<0.001). Conversion from prehypertension to hypertension is accelerated in blacks, which suggests that effective interventions in prehypertension could reduce racial disparities in prevalent hypertension.

Indexed as

Disease ProgressionAdolescentAdultAgedAged, 80 and overAge FactorsBlack or African AmericanBlack PeopleCohort StudiesDiabetes ComplicationsFemaleHumansHypertensionMaleMiddle AgedObesity

Identifiers

PMID21911708
PMCPMC3186683

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.