Evidence map›Paper›PMID 21911616›Full record

Trial reportThe Journal of physiology2011

Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia.

Anni Vanhatalo, Jonathan Fulford, Stephen J Bailey, James R Blackwell, Paul G Winyard, Andrew M Jones

2 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 93 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 4 pooled it
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01682356 phase1 / phase2completednot on this mapstarted 2012, after this paper: background citation

Dietary Nitrate for Heart Failure

TypeinterventionalSponsorWashington University School of MedicineRan2012 to 2023Enrolled17ConditionsHeart Failure, Hypertension, PulmonaryArmsBeetroot juice
NCT01725256 phase2terminatednot on this mapstarted 2012, after this paper: background citation

A Phase 2, Multi-Center, Open-label, Randomized, Parallel-Dose Study to Determine the Safety and Efficacy of AIR001 in Subjects With WHO Group 1 Pulmonary Arterial Hypertension (PAH)

TypeinterventionalSponsorAires Pharmaceuticals, Inc.Ran2012 to 2014Enrolled29ConditionsPulmonary Arterial HypertensionArmsAIR001 (sodium nitrite inhalation solution)
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 223 citations in OpenAlex.

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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Anni VanhataloCollege of Life and Environmental Sciences, University of Exeter School of Sport and Health Sciences, Heavitree Road, St Luke's Campus, Exeter EX1 2LU, UK. a.vanhatalo@exeter.ac.uk
Jonathan Fulford
Stephen J Bailey
James R Blackwell
Paul G Winyard
Andrew M Jones
University of Exeter · GBPeninsula Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exercise in hypoxia is associated with reduced muscle oxidative function and impaired exercise tolerance. We hypothesised that dietary nitrate supplementation (which increases plasma [nitrite] and thus NO bioavailability) would ameliorate the adverse effects of hypoxia on muscle metabolism and oxidative function. In a double-blind, randomised crossover study, nine healthy subjects completed knee-extension exercise to the limit of tolerance (T(lim)), once in normoxia (20.9% O(2); CON) and twice in hypoxia (14.5% O(2)). During 24 h prior to the hypoxia trials, subjects consumed 0.75 L of nitrate-rich beetroot juice (9.3 mmol nitrate; H-BR) or 0.75 L of nitrate-depleted beetroot juice as a placebo (0.006 mmol nitrate; H-PL). Muscle metabolism was assessed using calibrated (31)P-MRS. Plasma [nitrite] was elevated (P < 0.01) following BR (194 ± 51 nm) compared to PL (129 ± 23 nm) and CON (142 ± 37 nM). T(lim) was reduced in H-PL compared to CON (393 ± 169 vs. 471 ± 200 s; P < 0.05) but was not different between CON and H-BR (477 ± 200 s). The muscle [PCr], [P(i)] and pH changed at a faster rate in H-PL compared to CON and H-BR. The [PCr] recovery time constant was greater (P < 0.01) in H-PL (29 ± 5 s) compared to CON (23 ± 5 s) and H-BR (24 ± 5 s). Nitrate supplementation reduced muscle metabolic perturbation during exercise in hypoxia and restored exercise tolerance and oxidative function to values observed in normoxia. The results suggest that augmenting the nitrate-nitrite-NO pathway may have important therapeutic applications for improving muscle energetics and functional capacity in hypoxia.

Indexed as

Beta vulgarisAdultBlood PressureCross-Over StudiesDietary SupplementsDouble-Blind MethodExercise TestExercise ToleranceFemaleHumansHypoxiaMaleMuscle, SkeletalNitratesNitritesPlant ExtractsNitratesNitritesPlant Extracts

Identifiers

PMID21911616
PMCPMC3240888
OpenAlexW2120926785

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.