ArticleThe Journal of physiology2011
Kv1 channels control spike threshold dynamics and spike timing in cortical pyramidal neurones.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.
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Who cites it
68 citing papers in PubMed, 1 synthesis or guideline pooled it, 105 citations in OpenAlex.
- Modeling sources of interlaboratory variability in electrophysiological properties of mammalian neurons.Journal of neurophysiology · 2018Pooled it
- Fever-like temperatures improve cognitive deficits in the Scn2a autism mouse model via increases in potassium channel activity.Molecular psychiatry · 2026Article
- Compact photonic spiking neuron with inherent stochasticity based on phase-change material for probabilistic computing.Nature communications · 2026Article
- Bifurcation of spiking oscillations from a center in resonate-and-fire neurons.Biological cybernetics · 2026Article
- Adaptations of the axon initial segment in fast-spiking interneurons of the human neocortex support low action potential thresholds.PLoS biology · 2025Article
- KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Roles of KCNA2 in Neurological Diseases: from Physiology to Pathology.Molecular neurobiology · 2024Review
- Electrophysiological correlates of divergent projections in the avian superior olivary nucleus.Journal of neurophysiology · 2024Article
- Dynamic Gain Decomposition Reveals Functional Effects of Dendrites, Ion Channels, and Input Statistics in Population Coding.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Short-term neuronal and synaptic plasticity act in synergy for deviance detection in spiking networks.PLoS computational biology · 2023Article
- D-type K+ current rules the function of electrically coupled neurons in a species-specific fashion.The Journal of general physiology · 2023Article
- Kv2.1 Potassium Channels Regulate Repetitive Burst Firing in Extratelencephalic Neocortical Pyramidal Neurons.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Input rate encoding and gain control in dendrites of neocortical pyramidal neurons.Cell reports · 2022Article
- Ultrafast population coding and axo-somatic compartmentalization.PLoS computational biology · 2022Article
- Kv1 channels regulate variations in spike patterning and temporal reliability in the avian cochlear nucleus angularis.Journal of neurophysiology · 2022Article
- A NovelInternational journal of molecular sciences · 2021Article
- Different sensitivity of action potential generation to the rate of depolarization in vagal afferent A-fiber versus C-fiber neurons.Journal of neurophysiology · 2021Article
- Increased intrinsic excitability and decreased synaptic inhibition in aged somatosensory cortex pyramidal neurons.Neurobiology of aging · 2021Article
- Sparsely Distributed, Pre-synaptic Kv3 KFrontiers in cellular neuroscience · 2021Article
- Fragile X mental retardation protein modulates somatic D-type KJournal of neurophysiology · 2020Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies showed that cortical pyramidal neurones (PNs) have a dynamic spike threshold that functions as a high-pass filter, enhancing spike timing in response to high-frequency input. While it is commonly assumed that Na(+) channel inactivation is the primary mechanism of threshold accommodation, the possible role of K(+) channel activation in fast threshold changes has not been well characterized. The present study tested the hypothesis that low-voltage activated Kv1 channels affect threshold dynamics in layer 2-3 PNs, using α-dendrotoxin (DTX) or 4-aminopyridine (4-AP) to block these conductances. We found that Kv1 blockade reduced the dynamic changes of spike threshold in response to a variety of stimuli, including stimulus-evoked synaptic input, current steps and ramps of varied duration, and noise. Analysis of the responses to noise showed that Kv1 channels increased the coherence of spike output with high-frequency components of the stimulus. A simple model demonstrates that a dynamic spike threshold can account for this effect. Our results show that the Kv1 conductance is a major mechanism that contributes to the dynamic spike threshold and precise spike timing of cortical PNs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.