ArticleJournal of immunology (Baltimore, Md. : 1950)2011
Cohesin regulates MHC class II genes through interactions with MHC class II insulators.
Article in Journal of immunology (Baltimore, Md. : 1950), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Selective control of HLA-DRB1 and HLA-DQA1 transcription through DR/DQ super enhancer microelements.Cell reports · 2026Article
- The effect of cohesin mutations on HLA-class II expression in the myeloid leukemia of Down syndrome.Leukemia · 2026Article
- Article
- Cohesin-Mediated Chromatin Interactions and Autoimmunity.Frontiers in immunology · 2022Review
- Epigenetic gene regulation in plasma cells.Immunological reviews · 2021Review
- The Murine MHC Class II Super EnhancerJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Deciphering the Complexity of 3D Chromatin Organization Driving Lymphopoiesis and Lymphoid Malignancies.Frontiers in immunology · 2021Review
- A super enhancer controls expression and chromatin architecture within the MHC class II locus.The Journal of experimental medicine · 2020Article
- Developing in 3D: the role of CTCF in cell differentiation.Development (Cambridge, England) · 2018Review
- In the loop: promoter-enhancer interactions and bioinformatics.Briefings in bioinformatics · 2016Review
- Article
- NUDT2 Disruption Elevates Diadenosine Tetraphosphate (Ap4A) and Down-Regulates Immune Response and Cancer Promotion Genes.PloS one · 2016Article
- Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment.Nucleic acids research · 2015Article
- B cell differentiation is associated with reprogramming the CCCTC binding factor-dependent chromatin architecture of the murine MHC class II locus.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Mechanisms of cohesin-mediated gene regulation and lessons learned from cohesinopathies.Biochimica et biophysica acta · 2014Review
- The intellectual disability of trisomy 21: differences in gene expression in a case series of patients with lower and higher IQ.European journal of human genetics : EJHG · 2013Article
- The genomic landscape of cohesin-associated chromatin interactions.Genome research · 2013Article
- CTCF: the protein, the binding partners, the binding sites and their chromatin loops.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Higher-order orchestration of hematopoiesis: is cohesin a new player?Experimental hematology · 2012Review
- Cohesins repress Kaposi's sarcoma-associated herpesvirus immediate early gene transcription during latency.Journal of virology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cohesin is a multiprotein, ringed complex that is most well-known for its role in stabilizing the association of sister chromatids between S phase and M. More recently, cohesin was found to be associated with transcriptional insulators, elements that are associated with the organization of chromatin into regulatory domains. The human MHC class II (MHC-II) locus contains 10 intergenic elements, termed MHC-II insulators, which bind the transcriptional insulator protein CCCTC-binding factor. MHC-II insulators interact with each other, forming a base architecture of discrete loops and potential regulatory domains. When MHC-II genes are expressed, their proximal promoter regulatory regions reorganize to the foci established by the interacting MHC-II insulators. MHC-II insulators also bind cohesin, but the functional role of cohesin in regulating this system is not known. In this article, we show that the binding of cohesin to MHC-II insulators occurred irrespective of MHC-II expression but was required for optimal expression of the HLA-DR and HLA-DQ genes. In a DNA-dependent manner, cohesin subunits interacted with CCCTC-binding factor and the MHC-II-specific transcription factors regulatory factor X and CIITA. Intriguingly, cohesin subunits were important for DNA looping interactions between the HLA-DRA promoter region and a 5' MHC-II insulator but were not required for interactions between the MHC-II insulators themselves. This latter observation introduces cohesin as a regulator of MHC-II expression by initiating or stabilizing MHC-II promoter regulatory element interactions with the MHC-II insulator elements, events that are required for maximal MHC-II transcription.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.